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The International Collaboration on Air Pollution and Pregnancy Outcomes: initial results.: Air Pollution and Low Birth Weight

Jennifer Parker 1, * David Q. Rich 2 Svetlana V. Glinianaia 3 Jong Han Leem 4 Daniel Wartenberg 5 Michelle L. Bell 6 Matteo Bonzini 7 Michael Brauer 8 Lyndsey Darrow 9 Ulrike Gehring 10 Nelson Gouveia 11 Paolo Grillo 12 Eunhee Ha 13 Edith H. van den Hooven 14, 15 Bin Jalaludin 16, 17 Bill M. Jesdale 18 Johanna Lepeule 19 Rachel Morello-Frosch 18, 20 Geoffrey G. Morgan 16, 21 Rémy Slama 22 Frank H. Pierik 15 Angela Cecilia Pesatori 23 Sheela Sathyanarayana 24 Juhee Seo 13 Matthew Strickland 9 Lillian Tamburic 25 Tracey J. Woodruff 26 
Abstract : BACKGROUND: The findings of prior studies of air pollution effects on adverse birth outcomes are difficult to synthesize because of differences in study design. OBJECTIVES: The International Collaboration on Air Pollution and Pregnancy Outcomes was formed to understand how differences in research methods contribute to variations in findings. We initiated a feasibility study to a) assess the ability of geographically diverse research groups to analyze their data sets using a common protocol and b) perform location-specific analyses of air pollution effects on birth weight using a standardized statistical approach. METHODS: Fourteen research groups from nine countries participated. We developed a protocol to estimate odds ratios (ORs) for the association between particulate matter ≤ 10 μm in aerodynamic diameter (PM₁₀) and low birth weight (LBW) among term births, adjusted first for socioeconomic status (SES) and second for additional location-specific variables. RESULTS: Among locations with data for the PM₁₀ analysis, ORs estimating the relative risk of term LBW associated with a 10-μg/m³ increase in average PM₁₀ concentration during pregnancy, adjusted for SES, ranged from 0.63 [95% confidence interval (CI), 0.30-1.35] for the Netherlands to 1.15 (95% CI, 0.61-2.18) for Vancouver, with six research groups reporting statistically significant adverse associations. We found evidence of statistically significant heterogeneity in estimated effects among locations. CONCLUSIONS: Variability in PM₁₀-LBW relationships among study locations remained despite use of a common statistical approach. A more detailed meta-analysis and use of more complex protocols for future analysis may uncover reasons for heterogeneity across locations. However, our findings confirm the potential for a diverse group of researchers to analyze their data in a standardized way to improve understanding of air pollution effects on birth outcomes.
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Submitted on : Monday, February 14, 2011 - 4:55:18 PM
Last modification on : Friday, March 25, 2022 - 6:30:02 PM
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Jennifer Parker, David Q. Rich, Svetlana V. Glinianaia, Jong Han Leem, Daniel Wartenberg, et al.. The International Collaboration on Air Pollution and Pregnancy Outcomes: initial results.: Air Pollution and Low Birth Weight. Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2011, 119 (7), pp.1023-8. ⟨10.1289/ehp.1002725⟩. ⟨inserm-00565831⟩



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