NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousness.

Tahir Hakami 1 Nigel Jones 1 Elena Tolmacheva 2 Julien Gaudias 2 Joseph Chaumont 2 Michael Salzberg 3 Terence O'Brien 1 Didier Pinault 2, *
* Auteur correspondant
1 Department of Medicine
2 Physiopathologie clinique et expérimentale de la schizophrénie
3 Department of Psychiatry
Abstract : NMDAr antagonists acutely produces, in the rodent CNS, generalized aberrant gamma oscillations, which are not dependent on hyperlocomotion-related brain state or conscious sensorimotor processing. These findings suggest that NMDAr hypofunction-related generalized gamma hypersynchronies represent an aberrant diffuse network noise, a potential electrophysiological correlate of a psychotic-like state. Such generalized noise might cause dysfunction of brain operations, including the impairments in cognition and sensorimotor integration seen in schizophrenia.
keyword : schizophrenia EEG ketamine limbic system MK-801 noise schizophrenia.
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PLoS ONE, Public Library of Science, 2009, 4 (8), pp.e6755. 〈10.1371/journal.pone.0006755〉
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Tahir Hakami, Nigel Jones, Elena Tolmacheva, Julien Gaudias, Joseph Chaumont, et al.. NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousness.. PLoS ONE, Public Library of Science, 2009, 4 (8), pp.e6755. 〈10.1371/journal.pone.0006755〉. 〈inserm-00560002〉

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