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Journal articles
NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousness.
Abstract : NMDAr antagonists acutely produces, in the rodent CNS, generalized aberrant gamma oscillations, which are not dependent on hyperlocomotion-related brain state or conscious sensorimotor processing. These findings suggest that NMDAr hypofunction-related generalized gamma hypersynchronies represent an aberrant diffuse network noise, a potential electrophysiological correlate of a psychotic-like state. Such generalized noise might cause dysfunction of brain operations, including the impairments in cognition and sensorimotor integration seen in schizophrenia.
Cited literature [72 references]
https://www.hal.inserm.fr/inserm-00560002
Contributor : Didier Pinault <>
Submitted on : Thursday, January 27, 2011 - 4:56:12 PM
Last modification on : Thursday, April 23, 2020 - 2:26:29 PM
Long-term archiving on: : Thursday, April 28, 2011 - 2:40:25 AM
Contributor : Didier Pinault <>
Submitted on : Thursday, January 27, 2011 - 4:56:12 PM
Last modification on : Thursday, April 23, 2020 - 2:26:29 PM
Long-term archiving on: : Thursday, April 28, 2011 - 2:40:25 AM
File
journal.pone.0006755.pdf
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