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Application of click-click chemistry to the synthesis of new multivalent RGD conjugates.

Mathieu Galibert 1 Lucie Sancey 2 Olivier Renaudet 1 Jean-Luc Coll 3 Pascal Dumy 1 Didier Boturyn 1, *
* Corresponding author
1 DCM [2007-2015] - Département de Chimie Moléculaire [2007-2015]
2 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
3 INSERM U823, équipe 5 (cibles diagnostiques ou thérapeutiques et vectorisation de drogues dans le cancer du poumon)
INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
Abstract : New multivalent RGD-containing macromolecules were designed by exploiting two orthogonal chemoselective ligations. They were next applied to a competitive cell adhesion assay and used for the non invasive optical imaging of tumour in small animals.
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Mathieu Galibert, Lucie Sancey, Olivier Renaudet, Jean-Luc Coll, Pascal Dumy, et al.. Application of click-click chemistry to the synthesis of new multivalent RGD conjugates.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2010, 8 (22), pp.5133-8. ⟨10.1039/c0ob00070a⟩. ⟨inserm-00559554⟩

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