Nucleolin, a shuttle protein promoting infection of human monocytes by Francisella tularensis.
Abstract
We herein confirm the importance of nucleolin expression for LVS binding and its specificity as nucleolin is not involved in binding of another intracellular pathogen as L. monocytogenes or an inert particle. Association of nucleolin with F. tularensis during infection continues intracellularly after endocytosis of the bacteria. The present work therefore unravels for the first time the presence of nucleolin in the phagosomal compartment of macrophages.
Domains
Microbiology and Parasitology
Origin : Publisher files allowed on an open archive
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