Endothelial estrogen receptor {alpha} plays an essential role in the coronary and myocardial protective effects of estradiol in ischemia/reperfusion. - Archive ouverte HAL Access content directly
Journal Articles Arteriosclerosis, Thrombosis, and Vascular Biology Year : 2010

Endothelial estrogen receptor {alpha} plays an essential role in the coronary and myocardial protective effects of estradiol in ischemia/reperfusion.

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Abstract

Endothelial ERα plays a crucial role in the E2-induced prevention of endothelial dysfunction after I/R. To our knowledge, we demonstrate for the first time, by using unique genetically modified mice, that targeting endothelial protection per se can confer cardiomyocyte protection in I/R.

Dates and versions

inserm-00550876 , version 1 (31-12-2010)

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Julie Favre, Ji Gao, Jean-Paul Henry, Isabelle Remy-Jouet, Isabelle Fourquaux, et al.. Endothelial estrogen receptor {alpha} plays an essential role in the coronary and myocardial protective effects of estradiol in ischemia/reperfusion.. Arteriosclerosis, Thrombosis, and Vascular Biology, 2010, 30 (12), pp.2562-7. ⟨10.1161/ATVBAHA.110.213637⟩. ⟨inserm-00550876⟩
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