Synthesis of Cytotoxic Aza Analogues of Jaspine B.

Abstract : A straightforward access to pyrrolidine-based analogues of jaspine B was developed. Five stereoisomers were prepared including the all-cis derivatives presenting the configuration of the natural anhydrophytosphingosine. The synthesis of the latter relied on an original Staudinger-type cyclization process. The compounds were evaluated regarding their ability to alter tumor cells' viability and to interfere with the metabolism of sphingolipids.
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Journal of Organic Chemistry, American Chemical Society, 2010, epub ahead of print. 〈10.1021/jo1014239〉
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Soumis le : mercredi 29 décembre 2010 - 16:20:15
Dernière modification le : jeudi 13 septembre 2018 - 10:26:05

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Arnaud Rives, Sonia Ladeira, Thierry Levade, Nathalie Andrieu-Abadie, Yves Génisson. Synthesis of Cytotoxic Aza Analogues of Jaspine B.. Journal of Organic Chemistry, American Chemical Society, 2010, epub ahead of print. 〈10.1021/jo1014239〉. 〈inserm-00550705〉

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