The relation between type of farming and prevalence of Parkinson's disease among agricultural workers in five French districts.: Parkinson's disease and type of farming

Frédéric Moisan 1, * Johan Spinosi 2, 3 Jean-Luc Dupupet 4 Laurène Delabre 2 Jean-Louis Mazurie 5 Marcel Goldberg 2, 6 Ellen Imbernon 2 Christophe Tzourio 1 Alexis Elbaz 1, 2
* Auteur correspondant
1 Neuroépidémiologie
2 DST-InVS - Département santé travail
3 UMRESTTE UMR T9405 - Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement
4 Caisse centrale
5 Caisse départementale de la Gironde
6 CESP - Centre de recherche en épidémiologie et santé des populations
Abstract : Retrospective assessment of pesticide exposure is complex; however, patterns of pesticide use strongly depend on farming type, which is easier to assess than pesticide exposure. Our aim was to estimate Parkinson's disease (PD) prevalence in five French districts in 2007 among affiliates of Mutualité Sociale Agricole (MSA) and to investigate the relation between PD prevalence and farming type. We identified PD cases from administrative files as persons who used levodopa and/or benefited from free health care for PD. Densities of 16 farming types were defined at the canton of residence level (1988 French agricultural census). We used logistic regression to study the relation between PD prevalence and density of farming types and a semi-Bayes approach to deal with correlated exposures. We identified 1,659 PD cases, yielding an age- and sex-standardized PD prevalence of 3.01/1,000. Prevalence increased with age and was higher in men than women. We found a higher PD prevalence among affiliates living in cantons characterized by a higher density of farms specialized in fruits and permanent crops (multivariable semi-Bayes model: OR(4+5 vs 1+2+3 quintiles) = 1.21, 95% CI = 1.08-1.36; test for trend, P = 0.035). In France, farms specialized in fruits and permanent crops rank first in terms of insecticide use per hectare. Our findings are consistent with studies reporting an association between PD and insecticide use and show that workers in farms specialized in fruits or permanent crops may be an occupational group at higher PD risk.
Mots-clés : Agriculture Environmental Exposure Parkinson Disease Prevalence Pesticides
Type de document :
Article dans une revue
Movement Disorders, Wiley, 2011, 26 (2), pp.271-9. 〈10.1002/mds.23370〉
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http://www.hal.inserm.fr/inserm-00550264
Contributeur : Alexis Elbaz <>
Soumis le : mardi 13 décembre 2011 - 09:04:55
Dernière modification le : lundi 16 juillet 2018 - 14:20:02
Document(s) archivé(s) le : mercredi 14 mars 2012 - 02:20:15

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Frédéric Moisan, Johan Spinosi, Jean-Luc Dupupet, Laurène Delabre, Jean-Louis Mazurie, et al.. The relation between type of farming and prevalence of Parkinson's disease among agricultural workers in five French districts.: Parkinson's disease and type of farming. Movement Disorders, Wiley, 2011, 26 (2), pp.271-9. 〈10.1002/mds.23370〉. 〈inserm-00550264〉

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