B. A. Ahmed, B. C. Jeffus, S. I. Bukhari, J. T. Harney, R. Unal et al., Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter, J Biol Chem, vol.283, pp.9388-9398, 2008.

D. M. Angeles, J. Williams, R. E. Purdy, L. Zhang, P. et al., Effects of maturation and acute hypoxia on receptor-IP(3) coupling in ovine common carotid arteries, Am J Physiol Regul Integr Comp Physiol, vol.280, pp.410-417, 2001.

D. M. Angeles, J. Williams, L. Zhang, P. , and W. J. , Acute hypoxia modulates 5HT receptor density and agonist affinity in fetal and adult ovine carotid arteries, Am J Physiol Heart Circ Physiol, vol.279, pp.502-510, 2000.
DOI : 10.1152/ajpheart.2000.279.2.h502

A. K. Banes and S. W. Watts, Arterial Expression of 5-HT 2B and 5-HT 1B Receptors During Development of DOCA-salt Hypertension, BMC Pharmacol, vol.3, p.12, 2003.

G. B. Bhat and E. R. Block, Hypoxia directly increases serotonin transport by porcine pulmonary artery endothelial cell plasma membrane vesicles, Am J Respir Cell Mol Biol, vol.3, pp.363-367, 1990.
DOI : 10.1165/ajrcmb/3.4.363

P. Bianchi, O. Kunduzova, E. Masini, C. Cambon, D. Bani et al., Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury, Circulation, vol.112, pp.3297-3305, 2005.
DOI : 10.1161/circulationaha.104.528133
URL : https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.104.528133

S. Brune, T. Schmidt, U. Tebbe, and H. Kreuzer, Influence of long-term treatment with ketanserin on blood pressure, pulmonary artery pressure, and cardiac output in patients with heart failure, Cardiovasc Drugs Ther of Cardiovascular Pharmacotherapy, vol.4, pp.85-87, 1990.

C. I. Berul, M. E. Christe, and M. J. Aronovitz, Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities, J Interv Card Electrophysiol, vol.2, pp.7-14, 1998.

J. Callebert, J. M. Esteve, P. Hervé, K. Peoc'h, C. Tournois et al., Evidence for a control of plasma serotonin levels by 5Hydroxytryptamine 2B receptors in mice, J Pharmacol Exp Ther, vol.317, pp.724-731, 2006.
URL : https://hal.archives-ouvertes.fr/hal-01274937

A. M. Carneiro, E. H. Cook, D. L. Murphy, and R. D. Blakely, Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans, J Clin Invest, vol.118, pp.1544-1552, 2008.

D. S. Choi, S. J. Ward, N. Messaddeq, J. M. Launay, and L. Maroteaux, 5-HT 2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells, Development, vol.124, pp.1745-1755, 1997.

E. H. Cook, . Jr, K. E. Fletcher, M. Wainwright, N. Marks et al., Primary structure of the human platelet serotonin 5-HT 2A receptor: identify with frontal cortex serotonin 5-HT 2A receptor, J Neurochem, vol.63, pp.465-469, 1994.

F. Cote, C. Fligny, E. Bayard, J. M. Launay, M. D. Gershon et al., Maternal serotonin is crucial for murine embryonic development, Proc Natl Acad Sci U S A, vol.104, pp.329-334, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00166156

F. Côté, E. Thevenot, C. Fligny, Y. Fromes, M. Darmon et al., Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function, Proc Natl Acad Sci U S A, vol.100, pp.13525-13530, 2003.

Y. Dai, N. L. Dudek, T. B. Patel, and N. A. Muma, Transglutaminase-catalyzed Transamidation: A Novel Mechanism for Rac1 Activation by 5-HT 2A Receptor Stimulation, J Pharmacol Exp Ther, 2008.

G. L. Dale, P. Friese, P. Batar, S. F. Hamilton, G. L. Reed et al., Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface, Nature, vol.415, pp.175-179, 2002.

C. Davidson and J. A. Stamford, Serotonin efflux in the rat ventral lateral geniculate nucleus assessed by fast cyclic voltammetry is modulated by 5-HT 1B and 5-HT1D autoreceptors, Neuropharmacology, vol.35, pp.1627-1634, 1996.

S. Eddahibi, V. Fabre, C. Boni, M. P. Martres, B. Raffestin et al., Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin, Circ Res, vol.84, pp.329-336, 1999.

S. Eddahibi, N. Hanoun, L. Lanfumey, K. P. Lesch, B. Raffestin et al., Attenuated hypoxic pulmonary hypertension in mice lacking the 5hydroxytryptamine transporter gene, J Clin Invest, vol.105, pp.1555-1562, 2000.

J. M. Esteve, J. M. Launay, O. Kellermann, and L. Maroteaux, Functions of serotonin in hypoxic pulmonary vascular remodeling, Cell Biochem Biophys, vol.47, pp.33-44, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01274919

B. L. Fanburg and S. L. Lee, A role for the serotonin transporter in hypoxia-induced pulmonary hypertension, J Clin Invest, vol.105, pp.1521-1523, 2000.

H. W. Farber and J. Loscalzo, Pulmonary arterial hypertension, N Engl J Med, vol.351, pp.1655-1665, 2004.

C. Fligny, Y. Fromes, P. Bonnin, M. Darmon, E. Bayard et al., Maternal serotonin influences cardiac function in adult offspring, FASEB J, vol.22, pp.2340-2349, 2008.

X. W. Fu, C. A. Nurse, V. Wong, C. , and E. , Hypoxia-induced secretion of serotonin from intact pulmonary neuroepithelial bodies in neonatal rabbit, J Physiol, vol.539, pp.503-510, 2002.

C. Guilluy, S. Eddahibi, C. Agard, C. Guignabert, M. Izikki et al., RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling, American Journal of Respiratory and Critical Care Medicine, vol.179, pp.1151-1158, 2009.

C. Guilluy, M. Rolli-derkinderen, P. L. Tharaux, G. Melino, P. Pacaud et al., Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells, J Biol Chem, vol.282, pp.2918-2928, 2007.

P. Herve, L. Drouet, C. Dosquet, J. M. Launay, B. Rain et al., Primary pulmonary hypertension in a patient with a familial platelet storage pool disease: role of serotonin, Am J Med, vol.89, pp.117-120, 1990.

P. Herve, J. M. Launay, M. L. Scrobohaci, F. Brenot, G. Simonneau et al., Increased plasma serotonin in primary pulmonary hypertension, Am J Med, vol.99, pp.249-254, 1995.

J. Homberg, J. Mudde, B. Braam, B. Ellenbroek, E. Cuppen et al., Blood pressure in mutant rats lacking the 5-hydroxytryptamine transporter, Hypertension, vol.48, pp.115-116, 2006.

J. R. Homberg, T. Pattij, M. C. Janssen, E. Ronken, S. F. De-boer et al., Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility, Eur J Neurosci, vol.26, pp.2066-2073, 2007.

F. Jaffre, P. Bonnin, J. Callebert, H. Debbabi, V. Setola et al., Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy, Circ Res, vol.104, pp.113-123, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00484528

F. Jaffre, J. Callebert, A. Sarre, N. Etienne, C. G. Nebigil et al., Involvement of the serotonin 5-HT 2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1B eta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts, Circulation, vol.110, pp.969-974, 2004.

T. K. Jeffery and J. C. Wanstall, Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension, Pharmacol Ther, vol.92, pp.1-20, 2001.

C. Jonnakuty and C. Gragnoli, What do we know about serotonin?, J Cell Physiol, vol.217, issue.2, pp.301-307, 2008.

R. Kamel, S. Garcia, F. Lezoualc'h, R. Fischmeister, S. Muller et al., Immunomodulation by maternal autoantibodies of the fetal serotoninergic 5HT4 receptor and its consequences in early BALB/c mouse embryonic development, BMC Dev Biol, vol.7, p.34, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00165346

A. Keegan, I. Morecroft, D. Smillie, M. N. Hicks, and M. R. Maclean, Contribution of the 5-HT( 1B ) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT( 1B )-receptor knockout mice and the 5-HT( 1B /1D)-receptor antagonist GR127935, Circ Res, vol.89, pp.1231-1239, 2001.

I. M. Keith, J. A. Will, R. J. Huxtable, and K. Weir, Anti-platelet agents reduce morphological changes of chronic hypoxic pulmonary hypertension, Histol Histopathol, vol.2, pp.203-206, 1987.

D. Kentera, D. Susic, V. Veljkovic, G. Tucakovic, and V. Koko, Pulmonary artery pressure in rats with hereditary platelet function defect, Respiration, vol.54, pp.110-114, 1988.

A. Kereveur, J. Callebert, M. Humbert, P. Herve, G. Simonneau et al., High plasma serotonin levels in primary pulmonary hypertension. Effect of long-term epoprostenol (prostacyclin) therapy, Arterioscler Thromb Vasc Biol, vol.20, pp.2233-2239, 2000.

G. C. Kirby and D. S. Mcqueen, Effects of the antagonists MDL 72222 and ketanserin on responses of cat carotid body chemoreceptors to 5-hydroxytryptamine, Br J Pharmacol, vol.83, pp.259-269, 1984.

O. Lairez, D. Calise, P. Bianchi, C. Ordener, O. Spreux-varoquaux et al., Genetic deletion of MAOA promotes serotonin-dependent ventricular hypertrophy by pressure overload, J Mol Cell Cardiol, vol.46, pp.587-595, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00409926

J. M. Lauder, M. B. Wilkie, C. Wu, and S. Singh, Expression of 5-HT( 2A ), 5-HT( 2B ) and 5-HT( 2C ) receptors in the mouse embryo, Int J Dev Neurosci, vol.18, pp.653-662, 2000.

J. M. Launay, P. Herve, K. Peoc'h, C. Tournois, J. Callebert et al., Function of the serotonin 5hydroxytryptamine 2B receptor in pulmonary hypertension, Nat Med, vol.8, pp.1129-1135, 2002.
URL : https://hal.archives-ouvertes.fr/hal-01985063

J. M. Launay, S. Loric, V. Mutel, and O. Kellermann, The 5-HT 2B receptor controls the overall 5-HT transport system in the 1C11 serotonergic cell line, Ann N Y Acad Sci, vol.861, p.247, 1998.

S. L. Lee, W. W. Wang, B. J. Moore, and B. L. Fanburg, Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture, Circ Res, vol.68, pp.1362-1368, 1991.

N. Li, N. H. Wallen, M. Ladjevardi, and P. Hjemdahl, Effects of serotonin on platelet activation in whole blood, Blood Coagul Fibrinolysis, vol.8, pp.517-523, 1997.

A. E. Linder, W. Ni, T. Szasz, R. Burnett, J. Diaz et al., A serotonergic system in veins: serotonin transporter-independent uptake, J Pharmacol Exp Ther, vol.325, pp.714-722, 2008.

M. R. Maclean, G. A. Deuchar, M. N. Hicks, I. Morecroft, S. Shen et al., Overexpression of the 5hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxiainduced pulmonary hypertension, Circulation, vol.109, pp.2150-2155, 2004.

E. Marcos, S. Adnot, M. H. Pham, A. Nosjean, B. Raffestin et al., Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension, Am J Respir Crit Care Med, vol.168, pp.487-493, 2003.

R. B. Matondo, C. Punt, J. Homberg, M. J. Toussaint, R. Kisjes et al., Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration, Am J Physiol Gastrointest Liver Physiol, vol.296, pp.963-968, 2009.

T. P. Mcdonald, M. Cottrell, C. , and R. , Effects of short-term hypoxia on platelet counts of mice, Blood, vol.51, pp.165-175, 1978.

T. P. Mcdonald, M. B. Cottrell, S. A. Steward, R. E. Clift, C. J. Swearingen et al., Comparison of platelet production in two strains of mice with different modal megakaryocyte DNA ploidies after exposure to hypoxia, Exp Hematol, vol.20, pp.51-56, 1992.

A. Mekontso-dessap, F. Brouri, O. Pascal, P. Lechat, N. Hanoun et al., Deficiency of the 5hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice, Circulation, vol.113, pp.81-89, 2006.

L. Monassier, M. A. Laplante, F. Jaffre, P. Bousquet, L. Maroteaux et al., Serotonin 5-HT( 2B ) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice, Hypertension, vol.52, pp.301-307, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00484531

I. Morecroft, Y. Dempsie, M. Bader, D. J. Walther, K. Kotnik et al., Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension, Hypertension, vol.49, pp.232-236, 2007.

I. Morecroft, L. Loughlin, M. Nilsen, J. Colston, Y. Dempsie et al., Functional interactions between 5-hydroxytryptamine receptors and the serotonin transporter in pulmonary arteries, J Pharmacol Exp Ther, vol.313, pp.539-548, 2005.

C. G. Nebigil, P. Hickel, N. Messaddeq, J. L. Vonesch, M. P. Douchet et al., Ablation of serotonin 5-HT( 2B ) receptors in mice leads to abnormal cardiac structure and function, Circulation, vol.103, pp.2973-2979, 2001.

C. G. Nebigil, F. Jaffre, N. Messaddeq, P. Hickel, L. Monassier et al., Overexpression of the serotonin 5-HT 2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy, Circulation, vol.107, pp.3223-3229, 2003.

W. Ni, T. J. Geddes, J. R. Priestley, T. Szasz, D. M. Kuhn et al., The existence of a local 5-hydroxytryptaminergic system in peripheral arteries, Br J Pharmacol, vol.154, pp.663-674, 2008.

W. Ni, C. S. Wilhelm, M. Bader, D. L. Murphy, K. Lookingland et al., (+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5hydroxytryptamine or 5-hydroxytryptamine transporter, J Pharmacol Exp Ther, vol.314, pp.953-960, 2005.

N. Paulmann, M. Grohmann, J. Voigt, B. Bert, J. Vowinckel et al., Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation, PLoS Biol, vol.7, p.1000229, 2009.

L. M. Pavone, P. Mithbaokar, V. Mastellone, L. Avallone, P. Gaspar et al., Fate map of serotonin transporter-expressing cells in developing mouse heart, Genesis, vol.45, pp.689-695, 2007.

L. M. Pavone, A. Spina, R. Lo-muto, D. Santoro, V. Mastellone et al., Heart valve cardiomyocytes of mouse embryos express the serotonin transporter SERT, Biochem Biophys Res Commun, vol.377, pp.419-422, 2008.

B. R. Pitt, W. Weng, A. R. Steve, R. D. Blakely, I. Reynolds et al., Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture, Am J Physiol, vol.266, pp.178-186, 1994.

E. Qvigstad, T. Brattelid, I. Sjaastad, K. W. Andressen, K. A. Krobert et al., Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure, Cardiovasc Res, vol.65, issue.4, pp.869-78, 2005.

M. Rabinovitch, Linking a serotonin transporter polymorphism to vascular smooth muscle proliferation in patients with primary pulmonary hypertension, J Clin Invest, vol.108, pp.1109-1111, 2001.

M. M. Rapport, A. A. Green, P. , and I. H. , Crystalline Serotonin. Science, vol.108, pp.329-330, 1948.

M. M. Rapport, A. A. Green, P. , and I. H. , Serum vasoconstrictor, serotonin; isolation and characterization, J Biol Chem, vol.176, pp.1243-1251, 1948.

J. T. Reeves, B. M. Groves, and D. Turkevich, The case for treatment of selected patients with primary pulmonary hypertension, Am Rev Respir Dis, vol.134, pp.342-346, 1986.

P. A. Robiolio, V. H. Rigolin, J. S. Wilson, J. K. Harrison, L. L. Sanders et al., Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography, Circulation, vol.92, pp.790-795, 1995.

C. Rostagno, D. Prisco, M. Boddi, P. , and L. , Evidence for local platelet activation in pulmonary vessels in patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease, Eur Respir J, vol.4, pp.147-151, 1991.

C. Roux, M. Madani, J. Launay, F. Rey, D. Citadelle et al., Serotonin deficiency in phenylketonuria embryopathy, Toxicol in Vitro, vol.9, pp.653-662, 1995.

C. Sanchez and J. Hyttel, Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding, Cell Mol Neurobiol, vol.19, pp.467-489, 1999.

K. Sato, S. Webb, A. Tucker, M. Rabinovitch, R. F. O'brien et al., Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat, Am Rev Respir Dis, vol.145, pp.793-797, 1992.

V. Setola, R. , and B. L. , Why mice are neither miniature humans nor small rats: a cautionary tale involving 5-hydroxytryptamine-6 serotonin receptor species variants, Mol Pharmacol, vol.64, pp.1277-1278, 2003.

P. Steele, J. H. Ellis, . Jr, H. S. Weily, G. et al., Platelet survival time in patients with hypoxemia and pulmonary hypertension, Circulation, vol.55, pp.660-661, 1977.

T. Tolmachova, M. Abrink, C. E. Futter, K. S. Authi, and M. C. Seabra, Rab27b regulates number and secretion of platelet dense granules, Proc Natl Acad Sci U S A, vol.104, pp.5872-5877, 2007.

C. Tournois, V. Mutel, P. Manivet, J. M. Launay, and O. Kellermann, Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism, J Biol Chem, vol.273, pp.17498-17503, 1998.

D. N. Tu, A. R. Zou, Y. H. Liao, Y. M. Du, X. P. Wang et al., Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin, Sheng Li Xue Bao, vol.60, pp.525-534, 2008.

J. R. Vane, A sensitive method for the assay of 5-hydroxytryptamine, Br J Pharmacol Chemother, vol.12, pp.344-349, 1957.

M. Vially and V. Erspamer, Cellule entreocromaffine e cellule basigranulose acidofile nei vertebrati, Zeitschr f Zellforsch, vol.19, pp.743-773, 1933.

G. P. Vyssoulis, E. A. Karpanou, C. E. Pitsavos, A. A. Paleologos, T. K. Kourtis et al., Left ventricular hypertrophy regression and function changes with ketanserin in elderly hypertensives, Cardiovasc Drugs Ther, vol.4, pp.81-84, 1990.

D. J. Walther, J. U. Peter, S. Winter, M. Holtje, N. Paulmann et al., , 2003.

, Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release, Cell, vol.115, pp.851-862

J. C. Wanstall, S. A. Fiore, A. Gambino, and R. Chess-williams, Potentiation of 5hydroxytryptamine (5-HT) responses by a 5-HT uptake inhibitor in pulmonary and systemic vessels: effects of exposing rats to hypoxia, Naunyn Schmiedebergs Arch Pharmacol, vol.368, issue.6, pp.520-527, 2003.

S. W. Watts, The love of a lifetime: 5-HT in the cardiovascular system, Am J Physiol Regul Integr Comp Physiol, vol.296, pp.252-256, 2009.

S. W. Watts, J. R. Priestley, and J. M. Thompson, Serotonylation of vascular proteins important to contraction, PLoS ONE, vol.4, p.5682, 2009.

O. Weiss, Über die Wirkungen von Blutserum-Injectionen ins Blut, Archiv für die Gesamte Physiologie des Menschen und der Thiere. LXV, pp.215-230, 1896.

D. S. Woulfe, J. K. Lilliendahl, S. August, L. Rauova, M. A. Kowalska et al., Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice, Blood, vol.111, pp.3458-3467, 2008.