Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats. - Inserm - Institut national de la santé et de la recherche médicale

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Journal Articles Circulation Year : 2010

Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.

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Guillaume Gary-Bobo

Function : Author

Institut Mondor de Recherche Biomédicale

Service de chirurgie thoracique et d'anatomopathologie

Amal Houssaini

Function : Author

Institut Mondor de Recherche Biomédicale

Service de chirurgie thoracique et d'anatomopathologie

Valerie Amsellem

Function : Author

Institut Mondor de Recherche Biomédicale

Service de chirurgie thoracique et d'anatomopathologie

Dominique Rideau

Function : Author

Institut Mondor de Recherche Biomédicale

Service de chirurgie thoracique et d'anatomopathologie

Pierre Pacaud

Function : Author

Institut du thorax

Aline Perrin

Function : Author

Institut Mondor de Recherche Biomédicale

Service de chirurgie thoracique et d'anatomopathologie

Jérémy Brégeon

Function : Author

Institut du thorax

Elisabeth Marcos

Function : Author

Institut Mondor de Recherche Biomédicale

Service de chirurgie thoracique et d'anatomopathologie

Jean-Luc Dubois-Randé

Function : Author

Service de Cardiologie

Olivier Sitbon

Function : Author
PersonId : 763553
ORCID : 0000-0002-1942-1951
IdRef : 081152221

Service de pneumologie [Béclère]

Laurent Savale

Function : Author
PersonId : 761036
ORCID : 0000-0002-6862-8975
IdRef : 098817345

Institut Mondor de Recherche Biomédicale

Service de chirurgie thoracique et d'anatomopathologie

Serge Adnot

Function : Correspondent author
PersonId : 884940

Connectez-vous pour contacter l'auteur

Institut Mondor de Recherche Biomédicale

Service de chirurgie thoracique et d'anatomopathologie

Abstract

These results support an effect of HPIs on pulmonary vascular remodeling mediated by inhibition of Akt phosphorylation and consequently of pulmonary artery smooth muscle cell proliferation.

Keywords

AIDS pulmonary heart disease remodeling muscle smooth

Domains

Biochemistry, Molecular Biology

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HIV_def2_aw_.pdf (1.01 Mo)

inserm-00545885_edited.pdf (860.92 Ko)

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Origin : Files produced by the author(s)

Georges Guellaen : Connect in order to contact the contributor

https://www.hal.inserm.fr/inserm-00545885

Submitted on : Monday, May 9, 2011-8:23:25 AM

Last modification on : Wednesday, April 27, 2022-4:14:43 AM

Long-term archiving on: Wednesday, August 10, 2011-2:25:54 AM

Dates and versions

inserm-00545885 , version 1 (09-05-2011)

Identifiers

HAL Id : inserm-00545885 , version 1
DOI : 10.1161/CIRCULATIONAHA.110.973750
PUBMED : 20974998

Cite

Guillaume Gary-Bobo, Amal Houssaini, Valerie Amsellem, Dominique Rideau, Pierre Pacaud, et al.. Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.. Circulation, 2010, 122 (19), pp.1937-47. ⟨10.1161/CIRCULATIONAHA.110.973750⟩. ⟨inserm-00545885⟩

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