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Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.

Guillaume Gary-Bobo 1, 2 Amal Houssaini 1, 2 Valerie Amsellem 1, 2 Dominique Rideau 1, 2 Pierre Pacaud 3 Aline Perrin 1, 2 Jérémy Brégeon 3 Elisabeth Marcos 1, 2 Jean-Luc Dubois-Randé 4 Olivier Sitbon 5 Laurent Savale 1, 2 Serge Adnot 1, 2, * 
* Corresponding author
1 IMRB - Institut Mondor de Recherche Biomédicale
2 Service de chirurgie thoracique et d'anatomopathologie
3 Institut du thorax
4 Service de Cardiologie
5 Service de pneumologie [Béclère]
Abstract : These results support an effect of HPIs on pulmonary vascular remodeling mediated by inhibition of Akt phosphorylation and consequently of pulmonary artery smooth muscle cell proliferation.
Keywords : AIDS pulmonary heart disease remodeling muscle smooth
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Submitted on : Monday, May 9, 2011 - 8:23:25 AM
Last modification on : Wednesday, April 27, 2022 - 4:14:43 AM
Long-term archiving on: : Wednesday, August 10, 2011 - 2:25:54 AM

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Guillaume Gary-Bobo, Amal Houssaini, Valerie Amsellem, Dominique Rideau, Pierre Pacaud, et al.. Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.. Circulation, American Heart Association, 2010, 122 (19), pp.1937-47. ⟨10.1161/CIRCULATIONAHA.110.973750⟩. ⟨inserm-00545885⟩

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