T. Mashima, H. Seimiya, and T. Tsuruo, De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy, British Journal of Cancer, vol.282, issue.9, pp.1369-72, 2009.
DOI : 10.1038/sj.bjc.6605007

F. Kuhajda, Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology, Nutrition, vol.16, issue.3, pp.202-210, 2000.
DOI : 10.1016/S0899-9007(99)00266-X

F. Kuhajda, K. Jenner, and F. Wood, Fatty acid synthesis: a potential selective target for antineoplastic therapy., Proceedings of the National Academy of Sciences, vol.91, issue.14, pp.6379-83, 1994.
DOI : 10.1073/pnas.91.14.6379

P. Nagy, G. Vereb, and Z. Sebestyen, Lipid rafts and the local density of ErbB proteins influence the biological role of homo- and heteroassociations of ErbB2, Journal of Cell Science, vol.115, issue.22, pp.4251-62, 2002.
DOI : 10.1242/jcs.00118

J. Menendez and R. Lupu, Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis, Nature Reviews Cancer, vol.280, issue.10, pp.763-77, 2007.
DOI : 10.1038/nrc2222

J. Swinnen, K. Brusselmans, and G. Verhoeven, Increased lipogenesis in cancer cells: new players, novel targets, Current Opinion in Clinical Nutrition and Metabolic Care, vol.9, issue.4, pp.358-65, 2006.
DOI : 10.1097/01.mco.0000232894.28674.30

M. Miyazaki, M. Flowers, and H. Sampath, Hepatic Stearoyl-CoA Desaturase-1 Deficiency Protects Mice from Carbohydrate-Induced Adiposity and Hepatic Steatosis, Cell Metabolism, vol.6, issue.6, pp.484-96, 2007.
DOI : 10.1016/j.cmet.2007.10.014

S. Patra, Dissecting lipid raft facilitated cell signaling pathways in cancer, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1785, issue.2, pp.182-206, 2008.
DOI : 10.1016/j.bbcan.2007.11.002

J. Fu, V. Kodomuru, S. Sun, M. Winther, R. Fine et al., Nicotinamide derivatives and their use as therapeutic agents

D. Sarruf, I. Iankova, A. Abella, S. Assou, S. Miard et al., Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma, Mol Cell Biol, vol.22, pp.9985-95, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00144667

N. Scaglia and R. Igal, Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis, Int J Oncol, vol.4, pp.839-50, 2008.

R. Wilson and J. Sargent, Chain separation of monounsaturated fatty acid methyl esters by argentation thin-layer chromatography, Journal of Chromatography A, vol.905, issue.1-2, pp.251-258, 2001.
DOI : 10.1016/S0021-9673(00)01006-2

A. Abella, P. Dubus, and M. Malumbres, Cdk4 promotes adipogenesis through PPARgamma activation, Cell Metab, vol.4, pp.239-288, 2005.
DOI : 10.1016/j.cmet.2005.09.003

URL : https://hal.archives-ouvertes.fr/inserm-00144639

L. Fajas, V. Egler, and R. Reiter, The retinoblastoma-histone deacetylase 3 complex inhibits the peroxisome proliferator-activated receptor gamma and adipocyte differentiation, Developmental Cell, pp.903-910, 2002.

L. Fajas, V. Egler, R. Reiter, S. Miard, A. Lefebvre et al., PPARgamma controls cell proliferation and apoptosis in an RB-dependent manner, Oncogene, vol.27, pp.4186-93, 2003.

E. Pizer, B. Pflug, G. Bova, W. Han, M. Udan et al., Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression, The Prostate, vol.48, issue.2, pp.102-112, 2001.
DOI : 10.1002/pros.1052

S. Rossi, E. Graner, and P. Febbo, Fatty acid synthase expression defines distinct molecular signatures in prostate cancer, Mol Cancer Res, vol.10, pp.707-722, 2003.

M. Davies, D. Koul, and H. Dhesi, Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN, Cancer Res, vol.11, pp.2551-2557, 1999.

C. Kinkade, M. Castillo-martin, and A. Puzio-kuter, Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model, Journal of Clinical Investigation, vol.9, pp.3051-64, 2008.
DOI : 10.1172/JCI34764DS1

P. De-souza, R. P. Kearsley, and J. , Role of the Akt Pathway in Prostate Cancer, Current Cancer Drug Targets, vol.9, issue.2, pp.163-175, 2009.
DOI : 10.2174/156800909787581006

B. Manning and L. Cantley, AKT/PKB Signaling: Navigating Downstream, Cell, vol.129, issue.7, pp.1261-74, 2007.
DOI : 10.1016/j.cell.2007.06.009

URL : http://doi.org/10.1016/j.cell.2007.06.009

J. Kreisberg, S. Malik, and T. Prihoda, Phosphorylation of Akt (Ser473) is an Excellent Predictor of Poor Clinical Outcome in Prostate Cancer, Cancer Research, vol.64, issue.15, pp.5232-5238, 2004.
DOI : 10.1158/0008-5472.CAN-04-0272

M. Shen and C. Abate-shen, Pten Inactivation and the Emergence of Androgen-Independent Prostate Cancer, Cancer Research, vol.67, issue.14, pp.6535-6543, 2007.
DOI : 10.1158/0008-5472.CAN-07-1271

R. Elstrom, D. Bauer, and M. Buzzai, Akt Stimulates Aerobic Glycolysis in Cancer Cells, Cancer Research, vol.64, issue.11, pp.3892-3901, 2004.
DOI : 10.1158/0008-5472.CAN-03-2904

D. Bauer, G. Hatzivassiliou, F. Zhao, C. Andreadis, and C. Thompson, ATP citrate lyase is an important component of cell growth and transformation, Oncogene, vol.268, issue.41, pp.6314-6336, 2005.
DOI : 10.1038/sj.onc.1208773

T. Van-de-sande, D. Schrijver, E. Heyns, W. Verhoeven, G. Swinnen et al., Role of the phosphatidylinositol 3 -kinase/PTEN/Akt kinase pathway in the overexpression of ? fatty acid synthase in LNCaP prostate cancer cells, Cancer Res, vol.3, pp.642-648, 2002.

S. Bandyopadhyay, S. Pai, and M. Watabe, FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis, Oncogene, vol.7, issue.34, pp.5389-95, 2005.
DOI : 10.1006/excr.2002.5600

J. Li, Y. C. Liaw, and D. , PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer, Science, vol.275, issue.5308, pp.1943-1950, 1997.
DOI : 10.1126/science.275.5308.1943

M. Wymann and R. Schneiter, Lipid signalling in disease, Nature Reviews Molecular Cell Biology, vol.201, issue.2, pp.162-76, 2008.
DOI : 10.1038/nrm2335

D. Cross, D. Alessi, P. Cohen, M. Andjelkovich, and B. Hemmings, Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B, Nature, vol.270, issue.6559, pp.785-794, 1995.
DOI : 10.1038/378785a0

B. Zheng, J. Jeong, and J. Asara, Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation, Molecular Cell, vol.33, issue.2, pp.237-284, 2009.
DOI : 10.1016/j.molcel.2008.12.026

R. Rattan, S. Giri, A. Singh, and I. Singh, 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase, J Biol Chem, vol.47, pp.39582-93, 2005.

R. Jones, D. Plas, and S. Kubek, AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint, Molecular Cell, vol.18, issue.3, pp.283-93, 2005.
DOI : 10.1016/j.molcel.2005.03.027

URL : http://doi.org/10.1016/j.molcel.2005.03.027

D. Hardie, AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy, Nature Reviews Molecular Cell Biology, vol.367, issue.10, pp.774-85, 2007.
DOI : 10.1038/nrm2249

K. Inoki, H. Ouyang, and T. Zhu, TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth, Cell, vol.126, issue.5, pp.955-68, 2006.
DOI : 10.1016/j.cell.2006.06.055

Y. Long and J. Zierath, AMP-activated protein kinase signaling in metabolic regulation, Journal of Clinical Investigation, vol.116, issue.7, pp.1776-83, 2006.
DOI : 10.1172/JCI29044

M. Nadolski and M. Linder, Protein lipidation, FEBS Journal, vol.195, issue.20, pp.5202-5212, 2007.
DOI : 10.1111/j.1742-4658.2007.06056.x

R. Takada, Y. Satomi, and T. Kurata, Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion, Developmental Cell, vol.11, issue.6, pp.791-801, 2006.
DOI : 10.1016/j.devcel.2006.10.003

H. Voeller, G. Wilding, and E. Gelmann, v-rasH expression confers hormone-independent in vitro growth to LNCaP prostate carcinoma cells, Mol Endocrinol, vol.2, pp.209-225, 1991.

D. Gioeli, Signal transduction in prostate cancer progression, Clinical Science, vol.108, issue.4, pp.293-308, 2005.
DOI : 10.1042/CS20040329

H. Pearson, T. Phesse, and A. Clarke, K-ras and Wnt Signaling Synergize to Accelerate Prostate Tumorigenesis in the Mouse, Cancer Research, vol.69, issue.1, pp.94-101, 2009.
DOI : 10.1158/0008-5472.CAN-08-2895

T. Yamashita, M. Honda, and H. Takatori, Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma, Journal of Hepatology, vol.50, issue.1, 2009.
DOI : 10.1016/j.jhep.2008.07.036