Skip to Main content Skip to Navigation
Journal articles

MR-guided adaptive focusing of ultrasound.

Benoît Larrat 1, 2, * Mathieu Pernot 1, 2 Gabriel Montaldo 1, 2 Mathias Fink 1, 2 Mickaël Tanter 1, 2 
* Corresponding author
1 Physique des ondes pour la médecine
ESPCI Paris - Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, INSERM - Institut National de la Santé et de la Recherche Médicale : U979, CNRS - Centre National de la Recherche Scientifique : UMR7587
Abstract : Adaptive focusing of ultrasonic waves under the guidance of a magnetic resonance (MR) system is demonstrated for medical applications. This technique is based on the maximization of the ultrasonic wave intensity at one targeted point in space. The wave intensity is indirectly estimated from the local tissue displacement induced at the chosen focus by the acoustic radiation force of ultrasonic beams. Coded ultrasonic waves are transmitted by an ultrasonic array and an MRI scanner is used to measure the resulting local displacements through a motion-sensitive MR sequence. After the transmission of a set of spatially encoded ultrasonic waves, a non-iterative inversion process is employed to accurately estimate the spatial-temporal aberration induced by the propagation medium and to maximize the acoustical intensity at the target.Both programmable and physical aberrating layers introducing strong distortions (up to 2pi radians) were recovered within acceptable errors (<0.8 rad). This noninvasive technique is shown to accurately correct phase aberrations in a phantom gel with negligible heat deposition and limited acquisition time. These refocusing performances demonstrate a major potential in the field of MR-guided ultrasound therapy in particular for transcranial brain high-intensity focused ultrasound.
Document type :
Journal articles
Complete list of metadata

Cited literature [17 references]  Display  Hide  Download
Contributor : Mathieu Pernot Connect in order to contact the contributor
Submitted on : Friday, December 3, 2010 - 6:17:19 PM
Last modification on : Sunday, June 26, 2022 - 2:18:28 AM
Long-term archiving on: : Friday, March 4, 2011 - 4:33:09 AM


Files produced by the author(s)


  • HAL Id : inserm-00542902, version 1
  • PUBMED : 20704061


Benoît Larrat, Mathieu Pernot, Gabriel Montaldo, Mathias Fink, Mickaël Tanter. MR-guided adaptive focusing of ultrasound.. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Institute of Electrical and Electronics Engineers, 2010, 57 (8), pp.1734-7. ⟨inserm-00542902⟩



Record views


Files downloads