High power transcranial beam steering for ultrasonic brain therapy.

Abstract : A sparse phased array is specially designed for non-invasive ultrasound transskull brain therapy. The array is made of 200 single elements corresponding to a new generation of high power transducers developed in collaboration with Imasonic (Besançon, France). Each element has a surface of 0.5 cm2 and works at 0.9 MHz central frequency with a maximum 20 W cm(-2) intensity on the transducer surface. In order to optimize the steering capabilities of the array, several transducer distributions on a spherical surface are simulated: hexagonal, annular and quasi-random distributions. Using a quasi-random distribution significantly reduces the grating lobes. Furthermore, the simulations show the capability of the quasi-random array to electronically move the focal spot in the vicinity of the geometrical focus (up to +/- 15 mm). Based on the simulation study, the array is constructed and tested. The skull aberrations are corrected by using a time reversal mirror with amplitude correction achieved thanks to an implantable hydrophone, and a sharp focus is obtained through a human skull. Several lesions are induced in fresh liver and brain samples through human skulls, demonstrating the accuracy and the steering capabilities of the system.
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Physics in Medicine and Biology, IOP Publishing, 2003, 48 (16), pp.2577-89. 〈10.1109/TMI.2010.2076829〉
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Mathieu Pernot, Jean-François Aubry, Mickaël Tanter, Jean-Louis Thomas, Mathias Fink. High power transcranial beam steering for ultrasonic brain therapy.. Physics in Medicine and Biology, IOP Publishing, 2003, 48 (16), pp.2577-89. 〈10.1109/TMI.2010.2076829〉. 〈inserm-00542489〉

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