Systematic review reveals heterogeneity in definition of a clinically relevant difference in pain. - Archive ouverte HAL Access content directly
Journal Articles Journal of Clinical Epidemiology Year : 2011

Systematic review reveals heterogeneity in definition of a clinically relevant difference in pain.

(1) , (1, 2) , (1)
1
2

Abstract

OBJECTIVE: To describe the pain decrease considered as clinically relevant when designing a trial and reporting its results. METHODS: A systematic review of the literature in MEDLINE was conducted to select randomized controlled trials (RCTs) with pain as a primary outcome. Data extracted included the definition (terms and values) of a clinically relevant difference in pain, the type of pain studied (acute or chronic), the level of application (group or individual) of the clinically relevant difference, and the reference justifying the choice of value for clinically relevant difference. STUDY DESIGN AND SETTING: Seventy-four trials were included, and only 16 articles justified the choice of a value for clinically relevant difference with a reference citation. The values chosen for the clinically relevant relative decrease in pain varied from 4 to 40 mm or from 15% to 55% at the group level and from 20 to 50 mm at the individual level. In seven articles, the authors confused the application of the reference value at the individual or group level. CONCLUSION: Our review revealed a great heterogeneity in definition, format, and values of what is considered a clinically relevant difference in pain in RCTs of analgesics, and standardizations are advisable.
Fichier principal
Vignette du fichier
inserm-00541857_edited.pdf (272.19 Ko) Télécharger le fichier
Vignette du fichier
articlejclep_rev2.pdf (142.48 Ko) Télécharger le fichier
Vignette du fichier
Figure_1.doc (29 Ko) Télécharger le fichier
Vignette du fichier
Figure_2_jclep_rev.doc (26 Ko) Télécharger le fichier
Vignette du fichier
Table_1.doc (31 Ko) Télécharger le fichier
Vignette du fichier
Table_2_jclep.doc (50 Ko) Télécharger le fichier
Vignette du fichier
Table_3rw.doc (108.5 Ko) Télécharger le fichier
Vignette du fichier
Table_4.doc (24.5 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Format : Other
Format : Other
Format : Other
Format : Other
Format : Other
Format : Other
Loading...

Dates and versions

inserm-00541857 , version 1 (01-12-2010)

Identifiers

Cite

Adeline Ruyssen-Witrand, Florence Tubach, Philippe Ravaud. Systematic review reveals heterogeneity in definition of a clinically relevant difference in pain.: Definition of clinically relevant difference in pain assessment. Journal of Clinical Epidemiology, 2011, 64 (5), pp.463-70. ⟨10.1016/j.jclinepi.2010.06.008⟩. ⟨inserm-00541857⟩
185 View
812 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More