Skip to Main content Skip to Navigation
Journal articles

Analysis of the copy number profiles of several tumor samples from the same patient reveals the successive steps in tumorigenesis.

Abstract : We present a computational method, TuMult, for reconstructing the sequence of copy number changes driving carcinogenesis, based on the analysis of several tumor samples from the same patient. We demonstrate the reliability of the method with simulated data, and describe applications to three different cancers, showing that TuMult is a valuable tool for the establishment of clonal relationships between tumor samples and the identification of chromosome aberrations occurring at crucial steps in cancer progression.
Document type :
Journal articles
Complete list of metadatas

Cited literature [54 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00539062
Contributor : Georges Guellaen <>
Submitted on : Tuesday, November 23, 2010 - 7:45:11 PM
Last modification on : Wednesday, August 19, 2020 - 11:16:55 AM
Long-term archiving on: : Friday, October 26, 2012 - 4:40:19 PM

File

gb-2010-11-7-r76.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Eric Letouzé, Yves Allory, Marc Bollet, François Radvanyi, Frédéric Guyon. Analysis of the copy number profiles of several tumor samples from the same patient reveals the successive steps in tumorigenesis.. Genome Biology, BioMed Central, 2010, 11 (7), pp.R76. ⟨10.1186/gb-2010-11-7-r76⟩. ⟨inserm-00539062⟩

Share

Metrics

Record views

451

Files downloads

812