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Journal articles
Gait is associated with an increase in tonic firing of the sub-cuneiform nucleus neurons.
Brigitte Piallat
1
Stéphane Chabardès
1, 2
Napoleon Torres
1
Valérie Fraix
1
Laurent Goetz
1
Eric Seigneuret
2
Eric Bardinet
3
Muriel Ferraye
1
Bettina Debû
1
Paul Krack
1
Jérôme Yelnik
4
Pierre Pollak
1
Alim Louis Benabid
1, 2
Brigitte Piallat 1
Author
Stéphane Chabardès 1, 2
Author
Napoleon Torres 1
Author
Valérie Fraix 1
Author
Alim Louis Benabid 1, 2
Author
1
GIN - Grenoble Institut des Neurosciences (UJF - Site Santé La Tronche - BP 170 - 38042 Grenoble Cedex 9 - France)
- UJF - Université Joseph Fourier - Grenoble 1 (BP 53 - 38041 Grenoble Cedex 9 - France)
- CHU Grenoble (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U836 (101, rue de Tolbiac, 75013 Paris - France)
2
Pôle tête, cou et chirurgie réparatrice [Grenoble] (clinique de neurochirurgie, hôpital Michallon, B.P. 217, 38043 Grenoble cedex - France)
- CHU Grenoble (France)
3
NCIC - Neurosciences cognitives et imagerie cérébrale (47 Bvd de l'hôpital 75651 PARIS CEDEX 13 - France)
- CNRS - Centre National de la Recherche Scientifique : UPR640 (France)
4
Neurologie et thérapeutique expérimentale (GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U679 (101, rue de Tolbiac, 75013 Paris - France)
- IFR70 (France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
Abstract : In animals, the pedunculopontine (PPN) and the sub-cuneiform (SCU) nuclei located in the upper brainstem are involved during the processing of gait. Similar functional nuclei are suspected in humans but their role in gait is unclear. Here we show that, using extra-cellular recordings of the PPN/SCU region obtained in two parkinsonian patients, the SCU neurons increased their firing rate without modifying their firing pattern during mimicked steps. We conclude that SCU neurons are activated during gait processes.
Document type :
Journal articles
Complete list of metadatas
https://www.hal.inserm.fr/inserm-00536386
Contributor : Jean-Paul Issartel <>
Submitted on : Tuesday, November 16, 2010 - 10:21:03 AM
Last modification on : Friday, November 6, 2020 - 4:10:51 AM
Contributor : Jean-Paul Issartel <>
Submitted on : Tuesday, November 16, 2010 - 10:21:03 AM
Last modification on : Friday, November 6, 2020 - 4:10:51 AM
Identifiers
- HAL Id : inserm-00536386, version 1
- DOI : 10.1016/j.neuroscience.2008.10.046
- PUBMED : 19063948
Collections
INSERM | UPMC | CNRS | SORBONNE-UNIVERSITE | SU-MEDECINE | UGA
Citation
Brigitte Piallat, Stéphane Chabardès, Napoleon Torres, Valérie Fraix, Laurent Goetz, et al.. Gait is associated with an increase in tonic firing of the sub-cuneiform nucleus neurons.. Neuroscience, Elsevier - International Brain Research Organization, 2009, 158 (4), pp.1201-5. ⟨10.1016/j.neuroscience.2008.10.046⟩. ⟨inserm-00536386⟩
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