In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma.

Samuel Valable 1 Emmanuel Barbier 1 Myriam Bernaudin 2 Simon Roussel 2 Christoph Segebarth 1 Edwige Petit 2 Chantal Rémy 1, *
* Auteur correspondant
1 GIN - Grenoble Institut des Neurosciences
2 NMST - Neurodégénérescence : modèles et stratégies thérapeutiques
Abstract : This study has shown that murine monocytes/macrophages (Mo/Ma) can be labeled simply and efficiently with large, green-fluorescent, micrometer-sized particles of iron-oxide (MPIO). Neither size nor proliferation rate of the Mo/Ma is significantly affected by this labeling. The labeled Mo/Ma have been administered intravenously to rats that had developed a glioma following stereotactic injection of C6 cells. The labeled Mo/Ma were shown to target the brain tumors, a process that could be monitored non-invasively using T2*-weighted MRI. MRI observations were confirmed by Prussian blue staining, lectin staining and fluorescence histology. Overall, the results of this study suggest that the use of Mo/Ma may be envisaged in the clinic for vectorizing therapeutic agents toward gliomas.
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NeuroImage, Elsevier, 2008, 40 (2), pp.973-83
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Samuel Valable, Emmanuel Barbier, Myriam Bernaudin, Simon Roussel, Christoph Segebarth, et al.. In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma.. NeuroImage, Elsevier, 2008, 40 (2), pp.973-83. 〈inserm-00536177〉

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