Skip to Main content Skip to Navigation
Journal articles

Developmental and stress-induced remodeling of cell-cell communication in the adrenal medullary tissue.

Abstract : The adrenal medullary tissue contributes to maintain body homeostasis in reaction to stressful environmental changes via the release of catecholamines into the blood circulation in response to splanchnic nerve activation. Accordingly, chromaffin cell stimulus-secretion coupling undergoes temporally restricted periods of anatomo- functional remodeling in response to prevailing hormonal requirements of the organism. The postnatal development of the adrenal medulla and response to stress are remarkable physiological situations in which the stimulus- secretion coupling is critically affected. Catecholamine secretion from rat chromaffin cells is under a dual control involving an incoming initial command arising from the sympathetic nervous system that releases acetylcholine at the splanchnic nerve terminal-chromaffin cell synapses and a local gap junction-mediated intercellular communication. Interestingly, these two communication pathways are functionally interconnected within the gland and exhibit coordinated plasticity mechanisms. This article reviews the physiological and molecular evidence that the adrenal medullary tissue displays anatomical and functional adaptative remodeling of cell-cell communications upon physiological (postnatal development) and/or physiopathological (stress) situations associated with specific needs in circulating catecholamine levels.
Document type :
Journal articles
Complete list of metadatas

Cited literature [47 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00534622
Contributor : Nathalie C. Guerineau <>
Submitted on : Wednesday, November 10, 2010 - 10:57:16 AM
Last modification on : Friday, October 30, 2020 - 4:51:56 PM
Long-term archiving on: : Friday, February 11, 2011 - 2:48:39 AM

Files

Guerineau-Desarmenien_2010.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Nathalie Guérineau, Michel G Desarménien. Developmental and stress-induced remodeling of cell-cell communication in the adrenal medullary tissue.. Cellular and Molecular Neurobiology, Springer Verlag, 2010, 30 (8), pp.1425-31. ⟨10.1007/s10571-010-9583-z⟩. ⟨inserm-00534622⟩

Share

Metrics

Record views

329

Files downloads

707