Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.

Luc Dupuis 1, * Odile Spreux-Varoquaux 2 Gilbert Bensimon 3, 4 Philippe Jullien 2 Lucette Lacomblez 5, 6 François Salachas 5 Gaëlle Bruneteau 5 Pierre-François Pradat 5 Jean-Philippe Loeffler 1 Vincent Meininger 5
* Auteur correspondant
1 Laboratoire de signalisation moléculaire et neurodégénerescence
2 Service de Biologie, Unité de Pharmacologie
3 I3 - Immunologie - Immunopathologie - Immunothérapeutique
4 Service de pharmacologie biologique [CHU Pitié-Salpâtrière]
5 Fédération des Maladies du Système Nerveux
6 LIF - Laboratoire d'Imagerie Fonctionnelle
Abstract : BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease involving upper and lower motor neurons loss. Clinical features are highly variable among patients and there are currently few known disease-modifying factors underlying this heterogeneity. Serotonin is involved in a range of functions altered in ALS, including motor neuron excitability and energy metabolism. However, whether serotoninergic activity represents a disease modifier of ALS natural history remains unknown. METHODOLOGY: Platelet and plasma unconjugated concentrations of serotonin and plasma 5-HIAA, the major serotonin metabolite, levels were measured using HPLC with coulometric detection in a cohort of 85 patients with ALS all followed-up until death and compared to a control group of 29 subjects. PRINCIPAL FINDINGS: Platelet serotonin levels were significantly decreased in ALS patients. Platelet serotonin levels did not correlate with disease duration but were positively correlated with survival of the patients. Univariate Cox model analysis showed a 57% decreased risk of death for patients with platelet serotonin levels in the normal range relative to patients with abnormally low platelet serotonin (p = 0.0195). This protective effect remained significant after adjustment with age, gender or site of onset in multivariate analysis. Plasma unconjugated serotonin and 5-HIAA levels were unchanged in ALS patients compared to controls and did not correlate with clinical parameters. CONCLUSIONS/SIGNIFICANCE: The positive correlation between platelet serotonin levels and survival strongly suggests that serotonin influences the course of ALS disease.
Type de document :
Article dans une revue
PLoS ONE, Public Library of Science, 2010, 5 (10), pp.e13346. 〈10.1371/journal.pone.0013346〉
Liste complète des métadonnées

Littérature citée [39 références]  Voir  Masquer  Télécharger
http://www.hal.inserm.fr/inserm-00531253
Contributeur : Luc Dupuis <>
Soumis le : mardi 2 novembre 2010 - 11:29:53
Dernière modification le : mercredi 25 juillet 2018 - 01:24:45
Document(s) archivé(s) le : vendredi 2 décembre 2016 - 12:19:27

Fichier

plosoneserotonine.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

I3 | UPMC | LIB | UVSQ

Citation

Luc Dupuis, Odile Spreux-Varoquaux, Gilbert Bensimon, Philippe Jullien, Lucette Lacomblez, et al.. Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.. PLoS ONE, Public Library of Science, 2010, 5 (10), pp.e13346. 〈10.1371/journal.pone.0013346〉. 〈inserm-00531253〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

494

Téléchargements de fichiers

133

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD