A Cardiovascular Model for the Analysis of Pacing Configurations in Cardiac Resynchronization Therapy

Kevin Tse Ve Koon 1 Virginie Le Rolle 1, * Guy Carrault 1 Alfredo Hernandez 1, *
* Auteur correspondant
1 LTSI - Laboratoire Traitement du Signal et de l'Image
Abstract : A lumped-parameter model of the cardiovascular system, made of 3 interacting modules (an electrical heart model, an elastance-based mechanical heart model and a circulatory system) is proposed in this paper. This model is able to reproduce the clinically observed quasi-parabolic nature of the dependence of systolic blood pressure (SBP) on atrioventricular (AVD) and interventricular (VVD) delays and the increased SBP on AVD dependance at high heart rates. A sensitivity analysis has been performed on the main variables of this model, as well as parameter identification on interpolated clinical data. Results from these analyses show the importance of integrating the circulatory and regulatory systems for the reproduction of appropriate physiological responses to CRT.
Keywords : AVD SBP VVD atrioventricular delay cardiac resynchronization therapy cardiovascular model interventricular delay lumped-parameter model pacing configurations parameter identification sensitivity analysis systolic blood pressure
Type de document :
Communication dans un congrès
Computers In Cardiology, Sep 2009, Park City, UT, United States. IEEE Press, pp.393 - 396, 2010
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Kevin Tse Ve Koon, Virginie Le Rolle, Guy Carrault, Alfredo Hernandez. A Cardiovascular Model for the Analysis of Pacing Configurations in Cardiac Resynchronization Therapy. Computers In Cardiology, Sep 2009, Park City, UT, United States. IEEE Press, pp.393 - 396, 2010. 〈inserm-00530939〉

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