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Journal articles
Effects of depressive symptoms and coronary heart disease and their interactive associations on mortality in middle-aged adults: the Whitehall II cohort study.: Depression and mortality by CHD status
Abstract : BACKGROUND: Depression and mortality have been studied separately in patients with coronary heart disease (CHD) and in populations healthy at study inception. This does not allow comparisons across risk-factor groups based on the cross-classification of depression and CHD status. OBJECTIVE: To examine effects of depressive symptoms and CHD and their interactive associations on mortality in middle-aged adults followed over 5.6years. DESIGN AND SETTING: A prospective population-based cohort study of 5936 middle-aged men and women from the British Whitehall II study. We created four risk-factor groups based on the cross-classification of depressive symptoms and CHD status. RESULTS: The age-adjusted and sex-adjusted hazard ratios for death from all causes were 1.67 (p<0.05) for participants with only CHD, 2.10 (p<0.001) for those with only depressive symptoms and 4.99 (p<0.001) for those with both CHD and depressive symptoms when compared to participants without either condition. The two latter risk-factor groups remained at increased risk after adjustments for relevant confounders. The relative excess risk due to the interaction between depressive symptoms and CHD for all-cause mortality was 3.58 (95% CI -0.09 to 7.26), showing some evidence of an additive interaction. A similar pattern was also observed for cardiovascular death. CONCLUSIONS: This study provides evidence that depressive symptoms are associated with an increased risk of all-cause and cardiovascular death and that this risk is particularly marked in depressive participants with co-morbid CHD.
Cited literature [22 references]
https://www.hal.inserm.fr/inserm-00530265
Contributor : Nadine Kaniewski <>
Submitted on : Monday, February 21, 2011 - 8:50:16 AM
Last modification on : Wednesday, September 16, 2020 - 5:04:43 PM
Long-term archiving on: : Sunday, May 22, 2011 - 2:34:02 AM
Contributor : Nadine Kaniewski <>
Submitted on : Monday, February 21, 2011 - 8:50:16 AM
Last modification on : Wednesday, September 16, 2020 - 5:04:43 PM
Long-term archiving on: : Sunday, May 22, 2011 - 2:34:02 AM
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