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Anti-depressant medication use and C-reactive protein: results from two population-based studies.: Anti-depressants and systemic inflammation

Abstract : The use of anti-depressant medication has been linked to cardiovascular disease (CVD). We examined the association between anti-depressant medication use and a marker of low grade systemic inflammation as a potential pathway linking anti-depressant use and CVD in two population based studies. Data were collected in a representative sample of 8131 community dwelling adults (aged 47.4±15.9 years, 46.7% male) from the Scottish Health Surveys (SHS). The use of anti-depressant medication was coded according to the British National Formulary and blood was drawn for the measurement of C-reactive protein (CRP). In a second study, we attempted to replicate our findings using longitudinal data from the Whitehall II study (n=4584, aged 55.5±5.9 years, mean follow-up 5.5 years). Antidepressants were used in 5.6% of the SHS sample, with selective serotonin reuptake inhibitors (SSRIs) being the most common. There was a higher risk of elevated CRP (>3 mg/L) in users of tricyclic antidepressant (TCA) medication (multivariate adjusted odds ratio (OR)=1.52, 95% CI, 1.07-2.15), but not in SSRI users (multivariate adjusted OR=1.07, 95% CI, 0.81-1.42). A longitudinal association between any antidepressant use and subsequent CRP was confirmed in the Whitehall cohort. In summary, the use of anti-depressants was associated with elevated levels of systemic inflammation independently from the symptoms of mental illness and cardiovascular co-morbidity. This might be a potential mechanism through which antidepressant medication increases CVD risk. Further data are required to explore the effects of dosage and duration of antidepressant treatment.
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https://www.hal.inserm.fr/inserm-00530165
Contributor : Nadine Kaniewski <>
Submitted on : Wednesday, October 27, 2010 - 4:51:33 PM
Last modification on : Wednesday, September 16, 2020 - 5:04:43 PM
Long-term archiving on: : Friday, January 28, 2011 - 3:01:29 AM

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Mark Hamer, G. David Batty, Michael Marmot, Archana Singh-Manoux, Mika Kivimäki. Anti-depressant medication use and C-reactive protein: results from two population-based studies.: Anti-depressants and systemic inflammation. Brain, Behavior, and Immunity, Elsevier, 2011, 25 (1), pp.168-73. ⟨10.1016/j.bbi.2010.09.013⟩. ⟨inserm-00530165⟩

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