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Single cells spreading on a protein lattice adopt an energy minimizing shape.

Abstract : When spreading onto a protein microlattice living cells spontaneously acquire simple shapes determined by the lattice geometry. This suggests that, on a lattice, living cells' shapes are in thermodynamic metastable states. Using a model at thermodynamic equilibrium we are able to reproduce the observed shapes. We build a phase diagram based on two adimensional parameters characterizing essential cellular properties involved in spreading: the cell's compressibility and fluctuations.
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https://www.hal.inserm.fr/inserm-00529787
Contributor : Marc Block <>
Submitted on : Tuesday, October 26, 2010 - 3:41:00 PM
Last modification on : Thursday, November 19, 2020 - 1:01:19 PM
Long-term archiving on: : Thursday, January 27, 2011 - 2:45:31 AM

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Benoit Vianay, Jos Käfer, Emmanuelle Planus, Marc Block, François Graner, et al.. Single cells spreading on a protein lattice adopt an energy minimizing shape.. Physical Review Letters, American Physical Society, 2010, 105 (12), pp.128101. ⟨10.1103/PhysRevLett.105.128101⟩. ⟨inserm-00529787⟩

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