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Journal articles
Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study.
Evangelos Evangelou
1, 2
Demetrius Maraganore
3
Grazia Annesi
4
Laura Brighina
5
Alexis Brice
6
Alexis Elbaz
7
Carlo Ferrarese
5
Georgios Hadjigeorgiou
8, 9
Rejko Krueger
10
Jean-Charles Lambert
11
Suzanne Lesage
6
Katerina Markopoulou
8
George Mellick
12
Bram Meeus
13, 14, 15
Nancy Pedersen
16
Aldo Quattrone
17
Christine van Broeckhoven
13, 15
Manu Sharma
10
Peter Silburn
12
Eng-King Tan
18, 19
Karin Wirdefeldt
16
John Ioannidis
1, 20, 21, *
*
Corresponding author
Evangelos Evangelou 1, 2
Author
Demetrius M. Maraganore 3
Author
Grazia Annesi 4
Author
Laura Brighina 5
Author
Alexis Brice 6
Author
Alexis Elbaz 7
Author
Carlo Ferrarese 5
Author
Georgios M. Hadjigeorgiou 8, 9
Author
Rejko Krueger 10
Author
Jean-Charles Lambert 11
Author
Suzanne Lesage 6
Author
Katerina Markopoulou 8
Author
George D. Mellick 12
Author
Bram Meeus 13, 14, 15
Author
Nancy L. Pedersen 16
Author
Aldo Quattrone 17
Author
Christine van Broeckhoven 13, 15
Author
Manu Sharma 10
Author
Peter A. Silburn 12
Author
Eng-King Tan 18, 19
Author
Karin Wirdefeldt 16
Author
John P. A. Ioannidis 1, 20, 21
Correspondent author
1
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology (Medical School - GR-45110 Ioannina - Greece)
2
Institute of Microbiology (University Hospital, Lausanne - Switzerland)
- UNIL - Université de Lausanne (CH-1015 Lausanne - Switzerland)
3
Department of Neurology (Rochester, Minnesota - United States)
- Mayo Clinic College of Medicine (France)
5
Section of Neurology (Department of Neuroscience, Monza - Italy)
- UNIMIB - Università degli Studi di Milano-Bicocca [Milano] (Piazza dell'Ateneo Nuovo, 1 - 20126, Milano - Italy)
- San Gerardo Hospital (France)
6
Neurologie et thérapeutique expérimentale (GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U679 (101, rue de Tolbiac, 75013 Paris - France)
- IFR70 (France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
7
Neuroépidémiologie (GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U708 (101, rue de Tolbiac, 75013 Paris - France)
8
Laboratory of Neurogenetics, Deparment of Neurology (School of medicine, Larisa - Greece)
- UTH - University of Thessaly [Volos] (Argonafton & Filellinon, 38221 Volos - Greece)
10
Department of Neurology (Tuebingen - Germany)
- University Hospital Tuebingen (Germany)
- Hertie Institute for Clinical Brain Research (France)
11
Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations (Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX - France)
- Institut Pasteur de Lille (1 Rue du Professeur Calmette - Lille Cedex - 59019 - France)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U744 (101, rue de Tolbiac, 75013 Paris - France)
- Université de Lille, Droit et Santé (42 rue Paul Duez 59000 Lille - France)
12
Eskitis Institute for Cell and Molecular Therapies (School of Biomolecular & Physical Sciences, Nathan, QLD - Australia)
- Griffith University [Brisbane] (PO Box 3370 South Brisbane QLD 4101 - Australia)
13
Neurodegenerative Brain Diseases Group (Department of Molecular Genetics, Antwerpen - Belgium)
- VIB (France)
15
UA - University of Antwerp (Prinsstraat 13, 2000 Antwerpen - Belgium)
16
MEB - Department of Medical Epidemiology and Biostatistics (Karolinska Institutet SE-171 77 Stockholm - Sweden)
- Karolinska Institutet [Stockholm] (Solnavägen 1, 171 77 Solna Stockholm - Sweden)
17
Institute of Neurology (Catanzaro - Italy)
- UMG - Università degli Studi "Magna Graecia" di Catanzaro [Catanzaro, Italie] (Campus Universitario "Salvatore Venuta" Viale Europa - Loc. Germaneto (88100) CATANZARO - Italy)
18
Duke-NUS Medical School [Singapore] (8 College Road, Singapore 169857 - Singapore)
19
Department of Neurology (Singapore - Singapore)
- Singapore General Hospital (Singapore)
- National Neuroscience Institute (France)
20
Biomedical Research Institute (Ioannina - Greece)
- FORTH - Foundation for Research and Technology - Hellas (100 Nikolaou Plastira str., Vassilika Vouton, Heraklion, Crete GR 700 13 - Greece)
21
Institute for Clinical Research and Health Policy Studies (Tufts Medical Center, School of Medicine, Boston, Massachusetts - United States)
- Tufts Universiy (France)
Abstract : Early genome-wide association (GWA) studies on Parkinson's disease (PD) have not been able to yield conclusive, replicable signals of association, perhaps due to limited sample size. We aimed to investigate whether association signals derived from the meta-analysis of the first two GWA investigations might be replicable in different populations. We examined six single-nucleotide polymorphisms (SNPs) (rs1000291, rs1865997, rs2241743, rs2282048, rs2313982, and rs3018626) that had reached nominal significance with at least two of three different strategies proposed in a previous analysis of the original GWA studies. Investigators from the "Genetic Epidemiology of Parkinson's Disease" (GEOPD) consortium were invited to join in this study. Ten teams contributed replication data from 3,458 PD cases and 3,719 controls. The data from the two previously published GWAs (599 PD cases, 592 controls and 443 sibling pairs) were considered as well. All data were synthesized using both fixed and random effects models. The summary allelic odds ratios were ranging from 0.97 to 1.09 by random effects, when all data were included. The summary estimates of the replication data sets (excluding the original GWA data) were very close to 1.00 (range 0.98-1.09) and none of the effects were nominally statistically significant. The replication data sets had significantly different results than the GWA data. Our data do not support evidence that any of these six SNPs reflect susceptibility markers for PD. Much stronger signals of statistical significance in GWA platforms are needed to have substantial chances of replication. Specifically in PD genetics, this would require much larger GWA studies and perhaps novel analytical techniques.
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Journal articles
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https://www.hal.inserm.fr/inserm-00528836
Contributor : Marc Savasta <>
Submitted on : Wednesday, February 1, 2012 - 11:58:54 AM
Last modification on : Friday, June 11, 2021 - 9:28:06 AM
Long-term archiving on: : Tuesday, December 13, 2016 - 5:39:46 PM
Contributor : Marc Savasta <>
Submitted on : Wednesday, February 1, 2012 - 11:58:54 AM
Last modification on : Friday, June 11, 2021 - 9:28:06 AM
Long-term archiving on: : Tuesday, December 13, 2016 - 5:39:46 PM
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- HAL Id : inserm-00528836, version 1
- DOI : 10.1002/ajmg.b.30980
- PUBMED : 19475631
- PUBMEDCENTRAL : PMC4699803
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RIIP_LILLE | INSERM | UPMC | U836 | RIIP | SORBONNE-UNIVERSITE | SU-MEDECINE | SU-TI
Citation
Evangelos Evangelou, Demetrius Maraganore, Grazia Annesi, Laura Brighina, Alexis Brice, et al.. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study.. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Wiley, 2010, 153B (1), pp.220-8. ⟨10.1002/ajmg.b.30980⟩. ⟨inserm-00528836⟩
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