Skip to Main content Skip to Navigation
Journal articles

Sleep induced by stimulation in the human pedunculopontine nucleus area.

Abstract : The pedunculopontine nucleus is part of the reticular ascending arousal system and is involved in locomotion and sleep. Two patients with Parkinson disease received electrodes that stimulated the pedunculopontine nucleus area to alleviate their severe gait impairment. Instead, we found that low-frequency stimulation of the pedunculopontine nucleus area increased alertness, whereas high-frequency stimulation induced non-rapid eye movement sleep. In addition, the sudden withdrawal of the low-frequency stimulation was consistently followed by rapid eye movement sleep episodes in 1 patient. These data have the potential to benefit patients who suffer from sleep disorders.
Document type :
Journal articles
Complete list of metadatas

Cited literature [15 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00528797
Contributor : Marc Savasta <>
Submitted on : Wednesday, February 1, 2012 - 11:01:18 AM
Last modification on : Friday, November 6, 2020 - 3:52:44 AM
Long-term archiving on: : Tuesday, December 13, 2016 - 5:53:35 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Isabelle Arnulf, Muriel Ferraye, Valérie Fraix, Alim-Louis Benabid, Stephan Chabardès, et al.. Sleep induced by stimulation in the human pedunculopontine nucleus area.. Annals of Neurology, Wiley, 2010, 67 (4), pp.546-9. ⟨10.1002/ana.21912⟩. ⟨inserm-00528797⟩

Share

Metrics

Record views

236