In silico dynamic molecular interaction networks for the discovery of new therapeutic targets.

Todor Vujasinovic 1 André Sinisa Zampera 1 Pascale Jackers 2 Despina Sanoudou 3, 4 Antoine Depaulis 5
1 Helios BioSciences
2 MS LAB - Mass Spectrometry Laboratory
3 Department of Pharmacology
4 Molecular Biology Division
5 GIN - Grenoble Institut des Neurosciences
Abstract : Systems biology has emerged as a major trend in biological research during the past decade. As living organisms are described in more and more detail, it aims at filling the gap between understanding basic molecular processes and complex biological systems in which new properties often emerge from the combination of these elementary processes. This approach culminates in the development of computer-based mathematical models of physiological and pathophysiological processes. We review the state of the art in dynamic modelling, with emphasis on two complementary approaches: the modelling of small systems that is mostly developed by academic teams and aims at understanding generic biological properties, and the modelling of large systems that is mostly implemented by industrial companies and aims at the generation of new therapeutic strategies. We also provide an example of such large-scale modelling applied to the identification of drug targets for neurodegeneration.
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Article dans une revue
Current Pharmaceutical Design, Bentham Science Publishers, 2010, 16 (20), pp.2241-51
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http://www.hal.inserm.fr/inserm-00528462
Contributeur : Colin Deransart <>
Soumis le : jeudi 21 octobre 2010 - 17:36:59
Dernière modification le : jeudi 1 février 2018 - 01:11:41

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  • HAL Id : inserm-00528462, version 1
  • PUBMED : 20459389

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Todor Vujasinovic, André Sinisa Zampera, Pascale Jackers, Despina Sanoudou, Antoine Depaulis. In silico dynamic molecular interaction networks for the discovery of new therapeutic targets.. Current Pharmaceutical Design, Bentham Science Publishers, 2010, 16 (20), pp.2241-51. 〈inserm-00528462〉

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