Dentate gyrus and hilus transection blocks seizure propagation and granule cell dispersion in a mouse model for mesial temporal lobe epilepsy.

Johan Pallud 1 Ute Häussler 2 Mélanie Langlois 3 Sophie Hamelin 3 Bertrand Devaux 1 Colin Deransart 3 Antoine Depaulis 3
1 Service de neurochirurgie
2 Experimental Epilepsy, Neurocenter
3 GIN - Grenoble Institut des Neurosciences
Abstract : Epilepsy-associated changes of the anatomical organization of the dentate gyrus and hilus may play a critical role in the initiation and propagation of seizures in mesial temporal lobe epilepsy (MTLE). This study evaluated the role of longitudinal projections in the propagation of hippocampal paroxysmal discharges (HPD) in dorsal hippocampus by performing a selective transection in a mouse model for MTLE obtained by a single unilateral intrahippocampal injection of kainic acid (KA). Full transections of the dentate gyrus and hilus were performed in the transverse axis at 22 days after KA injection when spontaneous HPD were fully developed. They: (i) significantly reduced the occurrence of HPD; (ii) increased their duration at the KA injection site; (iii) abolished their spread along the longitudinal axis of the hippocampal formation and; (iv) limited granule cell dispersion (GCD) of the dentate gyrus posterior to the transection. These data suggest that: (i) longitudinal projections through the dentate gyrus and hilus are involved in HPD spread; (ii) distant hippocampal circuits participate in the generation and cessation of HPD and; (iii) GCD requires continuous HPD to develop, even when seizures are established. Our data reveal a critical role for longitudinal projections in the generation and spread of hippocampal seizures. © 2010 Wiley-Liss, Inc.
Type de document :
Article dans une revue
Hippocampus, Wiley, 2010, epub ahead of print. 〈10.1002/hipo.20795〉
Liste complète des métadonnées
http://www.hal.inserm.fr/inserm-00528343
Contributeur : Colin Deransart <>
Soumis le : jeudi 21 octobre 2010 - 15:53:45
Dernière modification le : jeudi 1 février 2018 - 01:11:41

Lien texte intégral

istex

Identifiants

Collections

UNIV-PARIS5 | UGA | USPC

Citation

Johan Pallud, Ute Häussler, Mélanie Langlois, Sophie Hamelin, Bertrand Devaux, et al.. Dentate gyrus and hilus transection blocks seizure propagation and granule cell dispersion in a mouse model for mesial temporal lobe epilepsy.. Hippocampus, Wiley, 2010, epub ahead of print. 〈10.1002/hipo.20795〉. 〈inserm-00528343〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

101

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD