Skip to Main content Skip to Navigation
Journal articles

Identification of Restricted Subsets of Mature microRNA Abnormally Expressed in Inactive Colonic Mucosa of Patients with Inflammatory Bowel Disease.

Abstract : BACKGROUND: Ulcerative Colitis (UC) and Crohn's Disease (CD) are two chronic Inflammatory Bowel Diseases (IBD) affecting the intestinal mucosa. Current understanding of IBD pathogenesis points out the interplay of genetic events and environmental cues in the dysregulated immune response. We hypothesized that dysregulated microRNA (miRNA) expression may contribute to IBD pathogenesis. miRNAs are small, non-coding RNAs which prevent protein synthesis through translational suppression or mRNAs degradation, and regulate several physiological processes. METHODOLOGY/FINDINGS: Expression of mature miRNAs was studied by Q-PCR in inactive colonic mucosa of patients with UC (8), CD (8) and expressed relative to that observed in healthy controls (10). Only miRNAs with highly altered expression (>5 or <0.2 -fold relative to control) were considered when Q-PCR data were analyzed. Two subsets of 14 (UC) and 23 (CD) miRNAs with highly altered expression (5.2->100 -fold and 0.05-0.19 -fold for over- and under- expression, respectively; 0.001
Document type :
Journal articles
Complete list of metadatas

Cited literature [78 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00528287
Contributor : André Groyer <>
Submitted on : Thursday, October 21, 2010 - 2:53:32 PM
Last modification on : Wednesday, August 19, 2020 - 11:16:43 AM
Long-term archiving on: : Saturday, January 22, 2011 - 2:50:41 AM

File

Fasseu_journal.pone.0013160.pd...
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Magali Fasseu, Xavier Tréton, Cécile Guichard, Eric Pedruzzi, Dominique Cazals-Hatem, et al.. Identification of Restricted Subsets of Mature microRNA Abnormally Expressed in Inactive Colonic Mucosa of Patients with Inflammatory Bowel Disease.. PLoS ONE, Public Library of Science, 2010, 5 (10), pp.e13160. ⟨10.1371/journal.pone.0013160⟩. ⟨inserm-00528287⟩

Share

Metrics

Record views

1183

Files downloads

1585