Characterisation of normal and cancer stem cells: one experimental paradigm for two kinds of stem cells.

Jean-François Mayol 1 Corinne Loeuillet 2 Francis Hérodin 1 Didier Wion 3, *
* Auteur correspondant
1 Centre de Recherches du Service de Santé des Armées
2 LAPM - Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble]
3 GIN - Grenoble Institut des Neurosciences
Abstract : The characterisation of normal stem cells and cancer stem cells uses the same paradigm. These cells are isolated by a fluorescence-activated cell sorting step and their stemness is assayed following implantation into animals. However, differences exist between these two kinds of stem cells. Therefore, the translation of the experimental procedures used for normal stem cell isolation into the research field of cancer stem cells is a potential source of artefacts. In addition, normal stem cell therapy has the objective of regenerating a tissue, while cancer stem cell-centred therapy seeks the destruction of the cancer tissue. Taking these differences into account is critical for anticipating problems that might arise in cancer stem cell-centred therapy and for upgrading the cancer stem cell paradigm accordingly.
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Article dans une revue
BioEssays, Wiley-VCH Verlag, 2009, 31 (9), pp.993-1001. 〈10.1002/bies.200900041〉
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http://www.hal.inserm.fr/inserm-00527767
Contributeur : Jean-Paul Issartel <>
Soumis le : mercredi 20 octobre 2010 - 11:29:34
Dernière modification le : jeudi 1 février 2018 - 01:11:41

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Jean-François Mayol, Corinne Loeuillet, Francis Hérodin, Didier Wion. Characterisation of normal and cancer stem cells: one experimental paradigm for two kinds of stem cells.. BioEssays, Wiley-VCH Verlag, 2009, 31 (9), pp.993-1001. 〈10.1002/bies.200900041〉. 〈inserm-00527767〉

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