Characterisation of normal and cancer stem cells: one experimental paradigm for two kinds of stem cells. - Archive ouverte HAL Access content directly
Journal Articles BioEssays Year : 2009

Characterisation of normal and cancer stem cells: one experimental paradigm for two kinds of stem cells.

(1) , (2) , (1) , (3)
1
2
3

Abstract

The characterisation of normal stem cells and cancer stem cells uses the same paradigm. These cells are isolated by a fluorescence-activated cell sorting step and their stemness is assayed following implantation into animals. However, differences exist between these two kinds of stem cells. Therefore, the translation of the experimental procedures used for normal stem cell isolation into the research field of cancer stem cells is a potential source of artefacts. In addition, normal stem cell therapy has the objective of regenerating a tissue, while cancer stem cell-centred therapy seeks the destruction of the cancer tissue. Taking these differences into account is critical for anticipating problems that might arise in cancer stem cell-centred therapy and for upgrading the cancer stem cell paradigm accordingly.

Dates and versions

inserm-00527767 , version 1 (20-10-2010)

Identifiers

Cite

Jean-François Mayol, Corinne Loeuillet, Francis Hérodin, Didier Wion. Characterisation of normal and cancer stem cells: one experimental paradigm for two kinds of stem cells.. BioEssays, 2009, 31 (9), pp.993-1001. ⟨10.1002/bies.200900041⟩. ⟨inserm-00527767⟩
160 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More