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Cellular FLICE-inhibitory protein: an attractive therapeutic target?

Olivier Micheau 1, * 
* Corresponding author
Abstract : Cellular FLIP (c-FLIP), also known as FLICE-inhibitory protein, has been identified as an inhibitor of apoptosis triggered by engagement of death receptors (DRs) such as Fas or TRAIL (TNF-related apoptosis-inducing ligand). cFLIP is recruited to DR signalling complexes, where it prevents caspase activation. Animal models have indicated that c-FLIP plays an important role in T cell proliferation and heart development. Abnormal c-FLIP expression has been identified in various diseases such as multiple sclerosis (MS), Alzheimer's disease (AD), diabetes mellitus, rheumatoid arthritis (RA) and various cancers. This review focuses on recent insights into c-FLIP dysregulation associated with human diseases and addresses the possibilities of using c-FLIP as a therapeutic target.
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Submitted on : Monday, October 18, 2010 - 10:55:12 AM
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Olivier Micheau. Cellular FLICE-inhibitory protein: an attractive therapeutic target?. Expert Opin Ther Targets, 2003, 7 (4), pp.559-73. ⟨10.1517/14728222.7.4.559⟩. ⟨inserm-00527112⟩



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