Skip to Main content Skip to Navigation
Journal articles

Microtubule-binding agents: a dynamic field of cancer therapeutics.

Abstract : Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an important therapeutic target in tumour cells. Agents that bind to microtubules have been part of the pharmacopoeia of anticancer therapy for decades and until the advent of targeted therapy, microtubules were the only alternative to DNA as a therapeutic target in cancer. The screening of a range of botanical species and marine organisms has yielded promising new antitubulin agents with novel properties. In the current search for novel microtubule-binding agents, enhanced tumour specificity, reduced neurotoxicity and insensitivity to chemoresistance mechanisms are the three main objectives.
Document type :
Journal articles
Complete list of metadata

Cited literature [192 references]  Display  Hide  Download
Contributor : Charles Dumontet Connect in order to contact the contributor
Submitted on : Monday, April 4, 2011 - 9:15:18 AM
Last modification on : Friday, October 23, 2020 - 4:45:22 PM
Long-term archiving on: : Tuesday, July 5, 2011 - 2:24:21 AM


Files produced by the author(s)




Charles Dumontet, Mary Ann Jordan. Microtubule-binding agents: a dynamic field of cancer therapeutics.. dressNature Reviews Drug Discovery, 2010, 9 (10), pp.790-803. ⟨10.1038/nrd3253⟩. ⟨inserm-00526519⟩



Record views


Files downloads