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Journal Articles dressNature Reviews Drug Discovery Year : 2010

Microtubule-binding agents: a dynamic field of cancer therapeutics.

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Abstract

Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an important therapeutic target in tumour cells. Agents that bind to microtubules have been part of the pharmacopoeia of anticancer therapy for decades and until the advent of targeted therapy, microtubules were the only alternative to DNA as a therapeutic target in cancer. The screening of a range of botanical species and marine organisms has yielded promising new antitubulin agents with novel properties. In the current search for novel microtubule-binding agents, enhanced tumour specificity, reduced neurotoxicity and insensitivity to chemoresistance mechanisms are the three main objectives.
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Origin : Files produced by the author(s)
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Origin : Files produced by the author(s)
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inserm-00526519 , version 1 (04-04-2011)

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Charles Dumontet, Mary Ann Jordan. Microtubule-binding agents: a dynamic field of cancer therapeutics.. dressNature Reviews Drug Discovery, 2010, 9 (10), pp.790-803. ⟨10.1038/nrd3253⟩. ⟨inserm-00526519⟩
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