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Targeting breast cancer stem cells: fishing season open!

Abstract : Studies describing tumor as a hierarchically-organized cell population have changed the classical oncogenesis view and proposes new therapeutic strategies. Cancer stem cells (CSC) are thought to sustain tumor initiation/maintenance, therapy resistance, and systemic metastases. Targeting this tumor cell population is crucial to achieve a true cure. A large research effort is now aiming atdeveloping drugs targeting CSCs based either on a priori understanding of key pathways regulating CSC biology or high-throughput screening to identify novel targets and compounds.
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https://www.hal.inserm.fr/inserm-00526321
Contributor : Christophe Ginestier <>
Submitted on : Monday, October 3, 2011 - 2:30:51 PM
Last modification on : Thursday, December 20, 2018 - 11:19:00 AM
Long-term archiving on: : Wednesday, January 4, 2012 - 2:20:24 AM

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  • HAL Id : inserm-00526321, version 1
  • PUBMED : 20887639

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Christophe Ginestier, Emmanuelle Charafe-Jauffret, Daniel Birnbaum. Targeting breast cancer stem cells: fishing season open!. Breast Cancer Research, BioMed Central, 2010, 12 (5), pp.312. ⟨inserm-00526321⟩

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