Abstract : Studies describing tumor as a hierarchically-organized cell population have changed the classical oncogenesis view and proposes new therapeutic strategies. Cancer stem cells (CSC) are thought to sustain tumor initiation/maintenance, therapy resistance, and systemic metastases. Targeting this tumor cell population is crucial to achieve a true cure. A large research effort is now aiming atdeveloping drugs targeting CSCs based either on a priori understanding of key pathways regulating CSC biology or high-throughput screening to identify novel targets and compounds.
http://www.hal.inserm.fr/inserm-00526321
Contributeur : Christophe Ginestier
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Soumis le : lundi 3 octobre 2011 - 14:30:51
Dernière modification le : mercredi 20 juin 2018 - 11:54:02
Document(s) archivé(s) le : mercredi 4 janvier 2012 - 02:20:24
Christophe Ginestier, Emmanuelle Charafe-Jauffret, Daniel Birnbaum. Targeting breast cancer stem cells: fishing season open!. Breast Cancer Research, BioMed Central, 2010, 12 (5), pp.312. 〈inserm-00526321〉
