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Targeting c-FLIP in cancer.

Abstract : Cellular-FLICE inhibitory protein (c-FLIP) is a key anti-apoptotic regulator that inhibits cell death mediated by the death receptors Fas, DR4, DR5, and TNF-R1. Three splice variants of c-FLIP function at the DISC level by blocking the processing and activation of procaspase-8 and -10. Overexpression of c-FLIP has been identified in many different tumour types, and its downregulation in vitro has been shown to restore apoptosis mediated by CD95L and TRAIL. c-FLIP therefore represents a promising target for cancer therapy. This review focuses on the molecular mechanisms that control c-FLIP expression and current research into inhibitors of the protein. Increasing evidence supports the investigation of c-FLIP as a therapeutic target to restore an apoptotic response in cancer cells.
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Contributor : Olivier Micheau Connect in order to contact the contributor
Submitted on : Monday, November 15, 2010 - 10:36:41 AM
Last modification on : Friday, May 20, 2022 - 9:06:06 AM
Long-term archiving on: : Friday, December 2, 2016 - 12:27:01 AM


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Sarah Shirley, Olivier Micheau. Targeting c-FLIP in cancer.. Cancer Letters, Elsevier, 2013, 332 (2), pp.141-50. ⟨10.1016/j.canlet.2010.10.009⟩. ⟨inserm-00525448⟩



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