Targeting c-FLIP in cancer. - Archive ouverte HAL Access content directly
Journal Articles Cancer Letters Year : 2013

Targeting c-FLIP in cancer.

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Abstract

Cellular-FLICE inhibitory protein (c-FLIP) is a key anti-apoptotic regulator that inhibits cell death mediated by the death receptors Fas, DR4, DR5, and TNF-R1. Three splice variants of c-FLIP function at the DISC level by blocking the processing and activation of procaspase-8 and -10. Overexpression of c-FLIP has been identified in many different tumour types, and its downregulation in vitro has been shown to restore apoptosis mediated by CD95L and TRAIL. c-FLIP therefore represents a promising target for cancer therapy. This review focuses on the molecular mechanisms that control c-FLIP expression and current research into inhibitors of the protein. Increasing evidence supports the investigation of c-FLIP as a therapeutic target to restore an apoptotic response in cancer cells.
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

inserm-00525448 , version 1 (15-11-2010)

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Sarah Shirley, Olivier Micheau. Targeting c-FLIP in cancer.. Cancer Letters, 2013, 332 (2), pp.141-50. ⟨10.1016/j.canlet.2010.10.009⟩. ⟨inserm-00525448⟩
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