Skip to Main content Skip to Navigation
Journal articles

Neurological signs and late-life depressive symptoms in a community population: the ESPRIT study.

Abstract : OBJECTIVE: Depression in the elderly is common and often resistant to treatment. It has been suggested that late-life depression may be related to underlying neurobiological changes. However, these observations are derived from diverse clinical samples and as yet have not been confirmed in a more representative population study. Our aim was to investigate associations between neurological signs as markers of underlying brain dysfunction and caseness for depression in an elderly community sample, controlling for physical health and comorbid/past neurological disorders. METHOD: A cross-sectional analysis of 2102 older people without dementia from the ESPRIT project. Depressive symptomatology was ascertained using the CES-D and abnormal neurological signs/comorbidity from a full neurological examination according to ICD-10 criteria. RESULTS: Pyramidal, extrapyramidal, cranial nerve and sensory deficit signs were significantly associated with case-level depressive symptoms. However, all odds ratios were close to null values in participants who did not have previous neurological disorder. CONCLUSIONS: We confirmed previous findings of an association between neurological signs and case-level depressive symptoms in late life. However, this association may simply reflect the impact of more severe comorbid neurological disorder.
Complete list of metadata

Cited literature [23 references]  Display  Hide  Download
Contributor : Dominique Villebrun Connect in order to contact the contributor
Submitted on : Thursday, October 7, 2010 - 12:08:26 PM
Last modification on : Tuesday, March 15, 2022 - 9:31:56 AM
Long-term archiving on: : Monday, January 10, 2011 - 11:24:53 AM


Files produced by the author(s)




Mishael Soremekun, Robert Stewart, Florence Portet, Sylvaine Artero, Marie-Laure Ancelin, et al.. Neurological signs and late-life depressive symptoms in a community population: the ESPRIT study.. International Journal of Geriatric Psychiatry, Wiley, 2010, 25 (7), pp.672-8. ⟨10.1002/gps.2406⟩. ⟨inserm-00524220⟩



Record views


Files downloads