Abstract : The contributions of (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and gamma-aminobutyric acid (GABA[A]) receptors in the induction of long-term potentiation (LTP) have been studied in the CA1 region of the rat hippocampus. The results suggest that: (1) in physiological conditions, AMPARs are necessary for the induction of N-methyl-D-aspartate receptor (NMDAR)-dependent LTP since LTP cannot be elicited in the presence of the AMPAR antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Although a NMDAR-dependent LTP occurs in the presence of a GABA(A) antagonist and high concentrations of divalents cations, blockade of AMPARs leads to a voltage-dependent calcium channels (VDCC)-dependent LTP since its induction is blocked by nifedipine and not by APV. (2) The bicarbonate-induced GABA(A) receptor-mediated depolarizing response is not necessary in the induction of NMDAR-dependent or VDCC-dependent LTP since induction of these two types of LTP were not blocked by acetazolamide or in a nominally bicarbonate-free solution.
http://www.hal.inserm.fr/inserm-00522471
Contributeur : Roman Tyzio
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Soumis le : jeudi 30 septembre 2010 - 16:56:35
Dernière modification le : mardi 11 octobre 2016 - 11:58:24
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C. Debray, Diabe Diabira, Jean-Luc Gaiarsa, Yezekiel Ben-Ari, Henri Gozlan. Contributions of AMPA and GABA(A) receptors to the induction of NMDAR-dependent LTP in CA1.. Neuroscience Letters, Elsevier, 1997, 238 (3), pp.119-22. 〈inserm-00522471〉
