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Journal articles
Contributions of AMPA and GABA(A) receptors to the induction of NMDAR-dependent LTP in CA1.
Abstract : The contributions of (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and gamma-aminobutyric acid (GABA[A]) receptors in the induction of long-term potentiation (LTP) have been studied in the CA1 region of the rat hippocampus. The results suggest that: (1) in physiological conditions, AMPARs are necessary for the induction of N-methyl-D-aspartate receptor (NMDAR)-dependent LTP since LTP cannot be elicited in the presence of the AMPAR antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Although a NMDAR-dependent LTP occurs in the presence of a GABA(A) antagonist and high concentrations of divalents cations, blockade of AMPARs leads to a voltage-dependent calcium channels (VDCC)-dependent LTP since its induction is blocked by nifedipine and not by APV. (2) The bicarbonate-induced GABA(A) receptor-mediated depolarizing response is not necessary in the induction of NMDAR-dependent or VDCC-dependent LTP since induction of these two types of LTP were not blocked by acetazolamide or in a nominally bicarbonate-free solution.
Cited literature [14 references]
https://www.hal.inserm.fr/inserm-00522471
Contributor : Roman Tyzio <>
Submitted on : Thursday, September 30, 2010 - 4:56:35 PM
Last modification on : Friday, March 27, 2020 - 2:23:39 AM
Long-term archiving on: : Friday, December 2, 2016 - 8:43:39 AM
Contributor : Roman Tyzio <>
Submitted on : Thursday, September 30, 2010 - 4:56:35 PM
Last modification on : Friday, March 27, 2020 - 2:23:39 AM
Long-term archiving on: : Friday, December 2, 2016 - 8:43:39 AM