[Synchroton radiotherapy].

Abstract : Radiation therapy is commonly used in the treatment of cancer. The normal tissue tolerance can be a limit to deliver enough dose to the tumor to be curative. The synchrotron beam presents some interesting physical properties, which could decrease this limitation. Synchrotron beam is a medium energy X-ray nearly parallel beam with high intensity. Three methods are under preclinical investigations: the microbeam, the minibeam and the stereotactic radiotherapy. The first two use a geometric irradiation effect called spatial fractioning. The last one use highly conformational irradiation geometry combined with a dose enhancement due to the presence of high-Z element in the target. Synchrotron radiotherapy preclinical experiments have shown some curative effect on rodent glioma models. Following these encouraging results a phase I/II clinical trial of iodinated enhanced stereotactic synchrotron radiotherapy is currently being prepared at the European Synchrotron Radiation Facility.
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Article dans une revue
La Revue De Médecine Interne, Elsevier, 2010, 31 (8), pp.586-9. 〈10.1016/j.revmed.2009.12.012〉
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Pierre Deman, M. Edouard, Sébastien Besse, Mathias Vautrin, Hélène Elleaume, et al.. [Synchroton radiotherapy].. La Revue De Médecine Interne, Elsevier, 2010, 31 (8), pp.586-9. 〈10.1016/j.revmed.2009.12.012〉. 〈inserm-00522394〉

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