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Nuclear stress bodies.

Giuseppe Biamonti 1 Claire Vourc'H 2, *
* Corresponding author
2 INSERM U823, équipe 10 (Stress et Dynamique de l'Organisation du Génome)
INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
Abstract : Nuclear stress bodies (nSBs) are unique subnuclear organelles which form in response to heat shock. They are initiated through a direct interaction between heat shock transcription factor 1 (HSF1) and pericentric tandem repeats of satellite III sequences and correspond to active transcription sites for noncoding satellite III transcripts. Given their unusual features, nSBs are distinct from other known transcription sites. In stressed cells, they are thought to participate in rapid, transient, and global reprogramming of gene expression through different types of mechanisms including chromatin remodeling and trapping of transcription and splicing factors. The analysis of these atypical and intriguing structures uncovers new facets of the relationship between nuclear organization and nuclear function.
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https://www.hal.inserm.fr/inserm-00521961
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Submitted on : Wednesday, September 29, 2010 - 10:42:32 AM
Last modification on : Friday, November 6, 2020 - 4:04:40 AM
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Giuseppe Biamonti, Claire Vourc'H. Nuclear stress bodies.. Cold Spring Harb Perspect Biol, 2010, 2 (6), pp.a000695. ⟨10.1101/cshperspect.a000695⟩. ⟨inserm-00521961⟩

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