Infection of semen-producing organs by SIV during the acute and chronic stages of the disease. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2008

Infection of semen-producing organs by SIV during the acute and chronic stages of the disease.

Résumé

BACKGROUND: Although indirect evidence suggests the male genital tract as a possible source of persistent HIV shedding in semen during antiretroviral therapy, this phenomenon is poorly understood due to the difficulty of sampling semen-producing organs in HIV+ asymptomatic individuals. METHODOLOGY/PRINCIPAL FINDINGS: Using a range of molecular and cell biological techniques, this study investigates SIV infection within reproductive organs of macaques during the acute and chronic stages of the disease. We demonstrate for the first time the presence of SIV in the testes, epididymides, prostate and seminal vesicles as early as 14 days post-inoculation. This infection persists throughout the chronic stage and positively correlates with blood viremia. The prostate and seminal vesicles appear to be the most efficiently infected reproductive organs, followed by the epididymides and testes. Within the male genital tract, mostly T lymphocytes and a small number of germ cells harbour SIV antigens and RNA. In contrast to the other organs studied, the testis does not display an immune response to the infection. Testosteronemia is transiently increased during the early phase of the infection but spermatogenesis remains unaffected. CONCLUSIONS/SIGNIFICANCE: The present study reveals that SIV infection of the macaque male genital tract is an early event and that semen-producing organs display differential infection levels and immune responses. These results help elucidate the origin of HIV in semen and constitute an essential base to improving the design of antiretroviral therapies to eradicate virus from semen.
Fichier principal
Vignette du fichier
journal.pone.0001792.pdf (744.78 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

inserm-00521466 , version 1 (29-09-2010)

Identifiants

Citer

Anna Le Tortorec, Roger Le Grand, Hélène Denis, Anne-Pascale Satie, Karim Mannioui, et al.. Infection of semen-producing organs by SIV during the acute and chronic stages of the disease.. PLoS ONE, 2008, 3 (3), pp.e1792. ⟨10.1371/journal.pone.0001792⟩. ⟨inserm-00521466⟩
199 Consultations
209 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More