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A genome-wide scan for common alleles affecting risk for autism.

Richard Anney 1 Lambertus Klei 2 Dalila Pinto 3 Regina Regan 4 Judith Conroy 4 Tiago Magalhaes 5, 6 Catarina Correia 5, 6 Brett Abrahams 7 Nuala Sykes 8 Alistair Pagnamenta 8 Joana Almeida 9 Elena Bacchelli 10 Anthony Bailey 11 Gillian Baird 12 Agatino Battaglia 13 Tom Berney 14 Nadia Bolshakova 1 Sven Bölte 15 Patrick Bolton 16 Thomas Bourgeron 17 Sean Brennan 1 Jessica Brian 18 Andrew Carson 3 Guillermo Casallo 3 Jillian Casey 4 Su Chu 2 Lynne Cochrane 1 Christina Corsello 19 Emily Crawford 20 Andrew Crossett 21 Geraldine Dawson 22, 23 Maretha de Jonge 24 Richard Delorme 25 Irene Drmic 18 Eftichia Duketis 15 Frederico Duque 9 Annette Estes 26 Penny Farrar 8 Bridget Fernandez 27 Susan Folstein 28 Eric Fombonne 29 Christine Freitag 15 John Gilbert 28 Christopher Gillberg 30 Joseph Glessner 31 Jeremy Goldberg 32 Jonathan Green 33 Stephen Guter 34 Hakon Hakonarson 31, 35 Elizabeth Heron 1 Matthew Hill 1 Richard Holt 8 Jennifer Howe 3 Gillian Hughes 1 Vanessa Hus 19 Roberta Igliozzi 13 Cecilia Kim 31 Sabine Klauck 36 Alexander Kolevzon 37 Olena Korvatska 38 Vlad Kustanovich 39 Clara Lajonchere 39 Janine Lamb 40 Magdalena Laskawiec 2 Marion Leboyer 41, 42 Ann Le Couteur 14 Bennett Leventhal 43, 44 Anath Lionel 3 Xiao-Qing Liu 3 Catherine Lord 19 Linda Lotspeich 13 Sabata Lund 20 Elena Maestrini 10 William Mahoney 45 Carine Mantoulan 46 Christian Marshall 3 Helen Mcconachie 14 Christopher Mcdougle 47 Jane Mcgrath 1 William Mcmahon 48 Nadine Melhem 2 Alison Merikangas 1 Ohsuke Migita 3 Nancy Minshew 49 Ghazala Mirza 8 Jeff Munson 50 Stanley Nelson 51 Carolyn Noakes 18 Abdul Noor 52 Gudrun Nygren 30 Guiomar Oliveira 9 Katerina Papanikolaou 53 Jeremy Parr 54 Barbara Parrini 13 Tara Paton 3 Andrew Pickles 55 Joseph Piven 56 David Posey 47 Annemarie Poustka 36 Fritz Poustka 15 Aparna Prasad 3 Jiannis Ragoussis 8 Katy Renshaw 2 Jessica Rickaby 3 Wendy Roberts 18 Kathryn Roeder 21 Bernadette Roge 46 Michael Rutter 57 Laura Bierut 58 John Rice 58 Jeff Salt 2 Katherine Sansom 3 Daisuke Sato 3 Ricardo Segurado 1 Lili Senman 18 Naisha Shah 4 Val Sheffield 59 Latha Soorya 37 Inês Sousa 8 Vera Stoppioni 60 Christina Strawbridge 32 Raffaella Tancredi 13 Katherine Tansey 1 Bhooma Thiruvahindrapduram 3 Ann Thompson 32 Susanne Thomson 20 Ana Tryfon 37 John Tsiantis 53 Herman van Engeland 24 John Vincent 52 Fred Volkmar 61 Simon Wallace 2 Kai Wang 31 Zhouzhi Wang 3 Thomas Wassink 62 Kirsty Wing 8 Kerstin Wittemeyer 46 Shawn Wood 2 Brian Yaspan 20 Danielle Zurawiecki 37 Lonnie Zwaigenbaum 63 Catalina Betancur 64 Joseph Buxbaum 37 Rita Cantor 51 Edwin Cook 34 Hilary Coon 48 Michael Cuccaro 28 Louise Gallagher 1 Daniel Geschwind 7 Michael Gill 1 Jonathan Haines 65 Judith Miller 48 Anthony Monaco 8 John Nurnberger 47 Andrew Paterson 3 Margaret Pericak-Vance 28 Gerard Schellenberg 66 Stephen Scherer 3 James Sutcliffe 20 Peter Szatmari 2 Astrid Vicente 5, 6 Veronica Vieland 67 Ellen Wijsman 68 Bernie Devlin 2, * Sean Ennis 4 Joachim Hallmayer 13
* Corresponding author
1 Division of Mental Health and Addiction
2 Department of Psychiatry [Pittsburgh]
3 Program in Genetics and Genomic Biology
4 ACoRD - Academic Centre on Rare Diseases
5 INSA - Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal]
6 BioFIG
7 Department of Neurology
8 The Wellcome Trust Centre for Human Genetics [Oxford]
9 UNDA - Unidade de Neurodesenvolvimento e Autismo
10 Department of Pharmacy and Biotechnology
11 Department of Psychiatry
12 Newcomen Centre
13 Department of Psychiatry and Behavioral Sciences [Stanford]
14 Child and Adolescent Mental Health
15 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy
16 Department of Child and Adolescent Psychiatry
17 Génétique Humaine et Fonctions Cognitives
18 Autism Research Unit
19 Autism and Communicative Disorders Centre
20 Department of Molecular Physiology & Biophysics and Psychiatry
21 Department of Statistics
22 Scientific Affairs
23 Department of Psychiatry
24 Department of Psychiatry
25 Service de psychopathologie de l'enfant et de l'adolescent
26 Department of Speech and Hearing Sciences [Washington]
27 Disciplines of Genetics and Medicine
28 John P. Hussman Institute for Human Genomics
29 Department of Child Psychiatry
30 Department of Child and Adolescent Psychiatry
31 The Center for Applied Genomics
32 Department of Psychiatry and Behavioural Neurosciences
33 Manchester Academic Health Sciences Centre
34 Department of Psychiatry
35 Department of Pediatrics
36 Division of Molecular Genome Analysis
37 Human Genetics Center
38 Department of Medicine
39 Autism Genetic Resource Exchange
40 Centre for Integrated Genomic Medical Research, Manchester
41 IUH - Institut Universitaire d'Hématologie
42 IMRB - Institut Mondor de Recherche Biomédicale
43 NKI - Nathan Kline Institute for Psychiatric Research
44 Department of Child and Adolescent Psychiatry
45 Department of Pediatrics
46 Centre d'Etudes et de Recherches en PsychoPathologie
47 Department of Psychiatry
48 Department of Developmental Neuroscience
49 Departments of Psychiatry and Neurology
50 Department of Psychiatry and Behavioral Sciences
51 Department of Human Genetics, Los Angeles
52 Centre for Addiction and Mental Health
53 University Department of Child Psychiatry
54 Institutes of Neuroscience and Health and Society
55 Department of Medicine, Manchester
56 Carolina Institute for Developmental Disabilities
57 Social, Genetic and Developmental Psychiatry Centre
58 Department of Psychiatry
59 Department of Pediatrics
60 Neuropsichiatria Infantile
61 Child Study Centre
62 Department of Psychiatry
63 Department of Pediatrics
64 Physiopathologie des Maladies du Système Nerveux Central
65 Vanderbilt Brain Institute
66 Pathology and Laboratory Medicine
67 Battelle Center for Mathematical Medicine
68 Departments of Biostatistics and Medicine
Abstract : Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10(-8). When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10(-8) threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C.
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Submitted on : Tuesday, September 28, 2010 - 3:19:33 PM
Last modification on : Wednesday, March 31, 2021 - 9:58:24 AM
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Richard Anney, Lambertus Klei, Dalila Pinto, Regina Regan, Judith Conroy, et al.. A genome-wide scan for common alleles affecting risk for autism.. Human Molecular Genetics, Oxford University Press (OUP), 2010, 19 (20), pp.4072-82. ⟨10.1093/hmg/ddq307⟩. ⟨inserm-00521391⟩

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