Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder.

Richard Delorme 1, 2 Daniel Moreno-De-Luca 3 Aurélie Gennetier 3 Wolfgang Maier 4 Pauline Chaste 1, 2 Rainald Mössner 4 Hans Jörgen Grabe 5 Stephan Ruhrmann 6 Peter Falkai 7 Marie-Christine Mouren 1 Marion Leboyer 2, 8 Michael Wagner 4 Catalina Betancur 3, *
* Auteur correspondant
1 Service de psychopathologie de l'enfant et de l'adolescent
2 IMRB - Institut Mondor de Recherche Biomédicale
3 Physiopathologie des Maladies du Système Nerveux Central
4 Department of Psychiatry and Psychotherapy
5 Department of Psychiatry and Psychotherapy
6 Department of Psychiatry and Psychotherapy
7 Department of Psychiatry and Psychotherapy
8 IUH - Institut Universitaire d'Hématologie
Abstract : BACKGROUND: Obsessive-compulsive disorder (OCD) is a clinically and etiologically heterogeneous syndrome. The high frequency of obsessive-compulsive symptoms reported in subjects with the 22q11.2 deletion syndrome (DiGeorge/velocardiofacial syndrome) or Prader-Willi syndrome (15q11-13 deletion of the paternally derived chromosome), suggests that gene dosage effects in these chromosomal regions could increase risk for OCD. Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients. METHODS: We screened the 15q11-13 and 22q11.2 chromosomal regions for genomic imbalances in 236 patients with OCD using multiplex ligation-dependent probe amplification (MLPA). RESULTS: No deletions or duplications involving 15q11-13 or 22q11.2 were identified in our patients. CONCLUSIONS: Our results suggest that deletions/duplications of chromosomes 15q11-13 and 22q11.2 are rare in OCD. Despite the negative findings in these two regions, the search for copy number variants in OCD using genome-wide array-based methods is a highly promising approach to identify genes of etiologic importance in the development of OCD.
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Article dans une revue
BMC Medical Genetics, BioMed Central, 2010, 11, pp.100. 〈10.1186/1471-2350-11-100〉
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Richard Delorme, Daniel Moreno-De-Luca, Aurélie Gennetier, Wolfgang Maier, Pauline Chaste, et al.. Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder.. BMC Medical Genetics, BioMed Central, 2010, 11, pp.100. 〈10.1186/1471-2350-11-100〉. 〈inserm-00520828〉

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