Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors. - Archive ouverte HAL Access content directly
Journal Articles BMJ Year : 2010

Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors.

(1, 2) , (1) , (2) , (1) , (1) , (1)
1
2

Abstract

OBJECTIVE: To estimate the percentage reduction in incidence of dementia that would be obtained if specific risk factors were eliminated. DESIGN: Prospective seven year cohort study. SETTING: General population, Montpellier, France. PARTICIPANTS: 1433 people aged over 65 with a mean baseline age of 72.5 (SD 5.1) years. MAIN OUTCOME MEASURES: Diagnosis of mild cognitive impairment or dementia established by a standardised neurological examination. RESULTS: Cox models were constructed to derive hazard ratios and determine confounding and interaction effects for potentially modifiable risk factors for dementia. Mean percentage population attributable fractions were calculated with 95% confidence intervals derived from bootstrapping for seven year incidence of mild cognitive impairment or dementia. The final model retained crystallised intelligence (population attributable fraction 18.11%, 95% confidence interval 10.91% to 25.42%), depression (10.31%, 3.66% to 17.17%), fruit and vegetable consumption (6.46%, 0.15% to 13.06%), diabetes (4.88%, 1.87% to 7.98%), and apolipoprotein E epsilon4 allele (7.11%, 2.44% to 11.98%). CONCLUSIONS: Increasing crystallised intelligence and fruit and vegetable consumption and eliminating depression and diabetes are likely to have the biggest impact on reducing the incidence of dementia, outweighing even the effect of removing the principal known genetic risk factor. Although causal relations cannot be concluded with certainty, the study suggests priorities that may inform public health programmes.
Fichier principal
Vignette du fichier
Ritchie_BMJ_341c3885.pdf (148.78 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

inserm-00520527 , version 1 (23-09-2010)

Identifiers

Cite

Karen Ritchie, Isabelle Carrière, Craig W. Ritchie, Claudine Berr, Sylvaine Artero, et al.. Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors.. BMJ, 2010, 341, pp.c3885. ⟨10.1136/bmj.c3885⟩. ⟨inserm-00520527⟩
105 View
225 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More