Skip to Main content Skip to Navigation
Journal articles

PEO coated magnetic nanoparticles for biomedical application

Abstract : This paper reports on the preparation, characterization and stealthiness of superparamagnetic nanoparticles (magnetite Fe3O4) with a 5 nm diameter and stabilized in water (pH > 6.5) by a shell of water-soluble poly(ethylene oxide) (PEO) chains. Two types of diblock copolymers, i.e., poly(acrylic acid)-b-poly(ethylene oxide), PAA-PEO, and poly(acrylic acid)-b-poly(acrylate methoxy poly(ethyleneoxide)), PAA-PAMPEO, were prepared as stabilizers with different compositions and molecular weights. At pH > 6.5, the negatively ionized PAA block interacts strongly with the positively-charged nanoparticles, thus playing the role of an anchoring block. Aggregates of coated nanoparticles were actually observed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The hydrodynamic diameter was in the 50-100 nm range and the aggregation number (number of nanoparticles per aggregate) was lying between several tens and hundred. Moreover, the stealthiness of these aggregates was assessed "in vitro" by the hemolytic CH50 test. No response of the complement system was observed, such that biomedical applications can be envisioned for these magnetic nanoparticles. Preliminary experiments of magnetic heating (10 kA/m; 108 kHz) were performed and specific absorption rate varied from 2 to 13 W/g(Fe).
Document type :
Journal articles
Complete list of metadatas

Cited literature [38 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00520136
Contributor : Delphine Autard <>
Submitted on : Wednesday, September 22, 2010 - 12:10:39 PM
Last modification on : Tuesday, July 23, 2019 - 10:42:04 AM
Long-term archiving on: : Thursday, December 23, 2010 - 3:00:37 AM

File

Aqil_20A_202008_20Eur_20Polym_...
Files produced by the author(s)

Identifiers

Collections

Citation

Abdelhafid Aqil, S. Vasseur, E. Duguet, Catherine Passirani, Jean-Pierre Benoît, et al.. PEO coated magnetic nanoparticles for biomedical application. European Polymer Journal, Elsevier, 2008, 44 (10), pp.3191-3199. ⟨10.1016/j.eurpolymj.2008.07.011⟩. ⟨inserm-00520136⟩

Share

Metrics

Record views

372

Files downloads

861