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Interactions between neurotensin receptors and G proteins.

Abstract : Three neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belong to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs). NTS1 and NTS2 may activate multiple signal transduction pathways, involving several G proteins. However, whereas NT acts as an agonist towards all NTS1-mediated pathways, this peptide may exert either agonist or antagonist activities, depending on the NTS2-mediated pathway in question. Studies on these receptors reinforce the concept of independence between multiple signals potentially mediated through a single GPCR, generating a wide diversity of functional responses depending on the host cell and the ligand.
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Contributor : Didier Pelaprat <>
Submitted on : Tuesday, September 21, 2010 - 12:43:52 PM
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Didier Pelaprat. Interactions between neurotensin receptors and G proteins.. Peptides / Peptides (Fayetteville), 2006, 27 (10), pp.2476-87. ⟨10.1016/j.peptides.2006.04.027⟩. ⟨inserm-00519739⟩



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