Distinct intracellular trafficking of hepatitis C virus in myeloid and plasmacytoid dendritic cells.

Mélanie Lambotin 1 Thomas Baumert 1, 2, * Heidi Barth 1
* Auteur correspondant
1 Interaction virus-hôte et maladies du foie
2 Service d'hépato-gastroentérologie
Abstract : Dendritic cells (DCs) are of pivotal importance for the initiation of immune responses to control and eliminate viral infections. The molecular mechanisms of hepatitis C virus (HCV) antigen uptake and processing by blood DCs are poorly defined. Here we show that human blood DC subsets acquire HCV independent of the classical HCV entry factors. Following HCV uptake, human plasmacytoid and myeloid DC subsets deliver HCV antigen into distinct endocytotic compartments, which are dedicated to presentation to CD4(+) or CD8(+) T cells. Our findings support a model of HCV antigen processing and presentation in which DC subsets fulfill distinct functions.
Type de document :
Article dans une revue
Journal of Virology, American Society for Microbiology, 2010, 84 (17), pp.8964-9. 〈10.1128/JVI.00517-10〉
Liste complète des métadonnées
http://www.hal.inserm.fr/inserm-00517147
Contributeur : Thomas Baumert <>
Soumis le : lundi 13 septembre 2010 - 16:01:09
Dernière modification le : lundi 18 décembre 2017 - 01:02:07
Document(s) archivé(s) le : mardi 14 décembre 2010 - 02:56:15

Fichiers

Lambotin_et_al_Fig1-3_JVI_Note...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Mélanie Lambotin, Thomas Baumert, Heidi Barth. Distinct intracellular trafficking of hepatitis C virus in myeloid and plasmacytoid dendritic cells.. Journal of Virology, American Society for Microbiology, 2010, 84 (17), pp.8964-9. 〈10.1128/JVI.00517-10〉. 〈inserm-00517147〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

132

Téléchargements de fichiers

231

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD