Skip to Main content Skip to Navigation
Journal articles

Distinct intracellular trafficking of hepatitis C virus in myeloid and plasmacytoid dendritic cells.

Abstract : Dendritic cells (DCs) are of pivotal importance for the initiation of immune responses to control and eliminate viral infections. The molecular mechanisms of hepatitis C virus (HCV) antigen uptake and processing by blood DCs are poorly defined. Here we show that human blood DC subsets acquire HCV independent of the classical HCV entry factors. Following HCV uptake, human plasmacytoid and myeloid DC subsets deliver HCV antigen into distinct endocytotic compartments, which are dedicated to presentation to CD4(+) or CD8(+) T cells. Our findings support a model of HCV antigen processing and presentation in which DC subsets fulfill distinct functions.
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00517147
Contributor : Thomas F. Baumert <>
Submitted on : Monday, September 13, 2010 - 4:01:09 PM
Last modification on : Thursday, November 26, 2020 - 3:56:04 PM
Long-term archiving on: : Tuesday, December 14, 2010 - 2:56:15 AM

Files

Lambotin_et_al_Fig1-3_JVI_Note...
Files produced by the author(s)

Identifiers

Collections

Citation

Mélanie Lambotin, Thomas Baumert, Heidi Barth. Distinct intracellular trafficking of hepatitis C virus in myeloid and plasmacytoid dendritic cells.. Journal of Virology, American Society for Microbiology, 2010, 84 (17), pp.8964-9. ⟨10.1128/JVI.00517-10⟩. ⟨inserm-00517147⟩

Share

Metrics

Record views

326

Files downloads

567