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Article Dans Une Revue Journal of Virology Année : 2010

Distinct intracellular trafficking of hepatitis C virus in myeloid and plasmacytoid dendritic cells.

Résumé

Dendritic cells (DCs) are of pivotal importance for the initiation of immune responses to control and eliminate viral infections. The molecular mechanisms of hepatitis C virus (HCV) antigen uptake and processing by blood DCs are poorly defined. Here we show that human blood DC subsets acquire HCV independent of the classical HCV entry factors. Following HCV uptake, human plasmacytoid and myeloid DC subsets deliver HCV antigen into distinct endocytotic compartments, which are dedicated to presentation to CD4(+) or CD8(+) T cells. Our findings support a model of HCV antigen processing and presentation in which DC subsets fulfill distinct functions.
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Dates et versions

inserm-00517147 , version 1 (13-09-2010)

Identifiants

Citer

Mélanie Lambotin, Thomas F. Baumert, Heidi Barth. Distinct intracellular trafficking of hepatitis C virus in myeloid and plasmacytoid dendritic cells.. Journal of Virology, 2010, 84 (17), pp.8964-9. ⟨10.1128/JVI.00517-10⟩. ⟨inserm-00517147⟩

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