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Angers 2 , and in CHU de Caen 3 ; values of activities are expressed as mean ± standard deviation and as nanomoles per minute and per milligram protein; I: respiratory complex I activity, i.e. rotenone-sensitive NADH ubiquinone oxidoreductase activity; II: respiratory complex II activity, i.e. succinate cytochrome c oxidoreductase activity; III: respiratory complex III activity, i.e. antimycin-sensitive ubiquinol cytochrome c oxidoreductase activity; IV: respiratory complex IV activity, i.e. cytochrome c oxidase activity; I + III: rotenone-sensitive NADH cytochrome c oxidoreductase activity; II + III: succinate cytochrome c oxidoreductase activity; CS: citrate synthase activity are the ratios of the corresponding activities; ?: data not available. Whatever the experimental conditions tested, rotenone sensitive I activity in control human skin fibroblasts suspension could appear to be null, La Salpêtrière hospital 1 This assay was therefore considered unreliable in these cell preparations. *: data obtained on only three samples ,