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Ca(2+) signaling by T-type Ca(2+) channels in neurons.

Abstract : Among the major families of voltage-gated Ca(2+) channels, the low-voltage-activated channels formed by the Ca(v)3 subunits, referred to as T-type Ca(2+) channels, have recently gained increased interest in terms of the intracellular Ca(2+) signals generated upon their activation. Here, we provide an overview of recent reports documenting that T-type Ca(2+) channels act as an important Ca(2+) source in a wide range of neuronal cell types. The work is focused on T-type Ca(2+) channels in neurons, but refers to non-neuronal cells in cases where exemplary functions for Ca(2+) entering through T-type Ca(2+) channels have been described. Notably, Ca(2+) influx through T-type Ca(2+) channels is the predominant Ca(2+) source in several neuronal cell types and carries out specific signaling roles. We also emphasize that Ca(2+) signaling through T-type Ca(2+) channels occurs often in select subcellular compartments, is mediated through strategically co-localized targets, and is exploited for unique physiological functions.
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Contributor : Marco Canepari Connect in order to contact the contributor
Submitted on : Monday, September 6, 2010 - 3:53:33 PM
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Lucius Cueni, Marco Canepari, John P. Adelman, Anita Lüthi. Ca(2+) signaling by T-type Ca(2+) channels in neurons.. Pflügers Archiv European Journal of Physiology, Springer Verlag, 2009, 457 (5), pp.1161-72. ⟨10.1007/s00424-008-0582-6⟩. ⟨inserm-00515354⟩



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