B. Vogelstein and K. Kinzler, The multistep nature of cancer, Trends in Genetics, vol.9, issue.4, pp.138-141, 1993.
DOI : 10.1016/0168-9525(93)90209-Z

B. David and R. Pieter, Liposomal nanomedicines, Expert Opin Drug Deliv, vol.5, pp.25-44, 2008.

B. Gupta, T. Levchenko, and V. Torchilin, Intracellular delivery of large molecules and small particles by, 2005.

S. Aroui, N. Ram, F. Appaix, M. Ronjat, A. Kenani et al., Maurocalcine as a Non Toxic Drug Carrier Overcomes Doxorubicin Resistance in the Cancer Cell Line MDA-MB 231, Pharmaceutical Research, vol.106, issue.Pt 4, pp.836-845, 2009.
DOI : 10.1007/s11095-008-9782-1

URL : https://hal.archives-ouvertes.fr/inserm-00356481

S. Aroui, S. Brahim, D. Waard, M. Bréard, J. Kenani et al., Efficient induction of apoptosis by doxorubicin coupled to cellpenetrating peptides compared to unconjugated doxorubicin in the human breast cancer cell line MDA-MB 231, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00410230

S. Wesselborg, I. Engels, E. Rossmann, M. Los, and K. Schulze-osthoff, Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction, Blood, vol.93, pp.3053-3063, 1999.

C. Scaffidi, S. Fulda, A. Srinivasan, C. Friesen, F. Li et al., Two CD95 (APO-1/Fas) signaling pathways, The EMBO Journal, vol.17, issue.6, pp.1675-1687, 1998.
DOI : 10.1093/emboj/17.6.1675

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170515

L. Butler, V. Liapis, S. Bouralexis, K. Welldon, S. Hay et al., The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, overcomes resistance of human breast cancer cells to Apo2L/TRAIL, International Journal of Cancer, vol.64, issue.4, pp.944-954, 2006.
DOI : 10.1002/ijc.21939

C. Lagadec, E. Adriaenssens, R. Toillon, V. Chopin, R. Romon et al., Tamoxifen and TRAIL synergistically induce apoptosis in breast cancer cells, Oncogene, vol.7, issue.10, pp.1472-1477, 2008.
DOI : 10.1074/jbc.M702804200

R. Pitti, S. Marsters, S. Ruppert, C. Donahue, A. Moore et al., Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family, J Biol Chem, vol.271, pp.12687-12690, 1996.

S. Baker and E. Reddy, Modulation of life and death by the TNF receptor superfamily, Oncogene, vol.17, issue.25, pp.3261-3270, 1998.
DOI : 10.1038/sj.onc.1202568

C. Dumitru, T. Carpinteiro, R. Hengge, and E. Gulbins, Doxorubicin enhances TRAIL-induced cell death via ceramide-enriched membrane platforms, Apoptosis, vol.314, issue.8, pp.1533-1541, 2007.
DOI : 10.1007/s10495-007-0081-9

L. Obeid, C. Linardic, L. Karolak, and Y. Hannun, Programmed cell death induced by ceramide, Science, vol.259, issue.5102, pp.1769-1771, 1993.
DOI : 10.1126/science.8456305

C. Bollinger, V. Teichgraber, and E. Gulbins, Ceramide-enriched membrane domains, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1746, issue.3, pp.284-294, 2005.
DOI : 10.1016/j.bbamcr.2005.09.001

S. Schutze, K. Potthoff, T. Machleidt, D. Berkovic, K. Wiegmann et al., TNF avtivates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced ''acidic'' sphingomyelin breakdown, Cell, vol.7192, pp.765-776, 1992.

Y. Zhang, P. Mattjus, P. Schmid, Z. Dong, S. Zhong et al., Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis, Journal of Biological Chemistry, vol.276, issue.15, pp.11775-11782, 2001.
DOI : 10.1074/jbc.M006000200

A. Haimovitz-friedman, C. Kan, D. Ehleiter, R. Persaud, M. Mcloughlin et al., Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis, Journal of Experimental Medicine, vol.180, issue.2, pp.525-5350022, 1994.
DOI : 10.1084/jem.180.2.525

S. Lacour, A. Hammann, S. Grazide, D. Lagadic-gossmann, A. Athias et al., Cisplatin-Induced CD95 Redistribution into Membrane Lipid Rafts of HT29 Human Colon Cancer Cells, Cancer Research, vol.64, issue.10, pp.3593-3598, 2004.
DOI : 10.1158/0008-5472.CAN-03-2787

C. Dumitru and E. Gulbins, TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis, Oncogene, vol.42, issue.41, pp.5612-5625, 2006.
DOI : 10.1038/sj.onc.1209568

Q. Zhao, T. Kondo, A. Noda, and Y. Fujiwara, Mitochondrial and intracellular free-calcium regulation of radiation-induced apoptosis in human leukemic cells, International Journal of Radiation Biology, vol.75, issue.4, pp.493-504, 1999.
DOI : 10.1080/095530099140429

D. Kim, S. Park, B. Nam, I. Kim, and S. Kim, Reversal of Drug Resistance in Breast Cancer Cells by Transglutaminase 2 Inhibition and Nuclear Factor-??B Inactivation, Cancer Research, vol.66, issue.22, pp.10936-10943, 2006.
DOI : 10.1158/0008-5472.CAN-06-1521

B. Barnhart, E. Alappat, and M. Peter, The CD95 Type I/Type II model, Seminars in Immunology, vol.15, issue.3, pp.185-19310, 2003.
DOI : 10.1016/S1044-5323(03)00031-9

X. Wu, X. Jin, Y. Zeng, E. Hamed, A. Kakehi et al., Low concentrations of doxorubicin sensitizes human solid cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-receptor (R) 2-mediated apoptosis by inducing TRAIL-R2 expression, Cancer Science, vol.61, issue.12, pp.1969-1976, 2007.
DOI : 10.1006/bbrc.1999.1641

D. Delmas, R. C. Micheau, O. Athias, A. Gambert, P. Grazide et al., Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells, Oncogene, vol.23, issue.55, pp.8979-8986, 2004.
DOI : 10.1038/sj.onc.1208086

F. Psahoulia, K. Drosopoulos, L. Doubravska, L. Andera, and A. Pintzas, Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts, Molecular Cancer Therapeutics, vol.6, issue.9, 2007.
DOI : 10.1158/1535-7163.MCT-07-0001

K. Simons and D. Toomre, Lipid rafts and signal transduction, Nature Reviews Molecular Cell Biology, vol.1, issue.1, pp.31-39, 2000.
DOI : 10.1038/35036052

A. Christian, M. Haynes, M. Phillips, and G. Rothblat, Use of cyclodextrins for manipulating cellular cholesterol content, J Lipid Res, vol.38, pp.2264-2272, 1997.

S. Shankar, X. Chen, and R. Srivastava, Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo, The Prostate, vol.55, issue.2, pp.165-186, 2005.
DOI : 10.1002/pros.20126

J. Kang, J. Bu, Y. Hao, and F. Chen, Subtoxic concentration of doxorubicin enhances TRAIL-induced apoptosis in human prostate cancer cell line LNCaP, Prostate Cancer and Prostatic Diseases, vol.338, issue.3, pp.274-279, 2005.
DOI : 10.1002/pros.10155

X. Jin, X. Wu, A. Nouh, M. Kakehi, and Y. , Enhancement of Death Receptor 4 Mediated Apoptosis and Cytotoxicity in Renal Cell Carcinoma Cells by Subtoxic Concentrations of Doxorubicin, The Journal of Urology, vol.177, issue.5, pp.1894-1899, 2007.
DOI : 10.1016/j.juro.2007.01.018

M. Peter and P. Krammer, Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis, Current Opinion in Immunology, vol.10, issue.5, pp.545-551, 1998.
DOI : 10.1016/S0952-7915(98)80222-7

C. Gajate, D. Canto-jañez, E. Acuña, A. Amat-guerri, F. Geijo et al., Intracellular Triggering of Fas Aggregation and Recruitment of Apoptotic Molecules into Fas-enriched Rafts in Selective Tumor Cell Apoptosis, The Journal of Experimental Medicine, vol.11, issue.3, pp.353-365, 2004.
DOI : 10.1074/jbc.M308352200

D. Delmas, C. Rébé, S. Lacour, R. Filomenko, A. Athias et al., Resveratrol-induced Apoptosis Is Associated with Fas Redistribution in the Rafts and the Formation of a Death-inducing Signaling Complex in Colon Cancer Cells, Journal of Biological Chemistry, vol.278, issue.42, pp.41482-41490, 2003.
DOI : 10.1074/jbc.M304896200

R. Neve, K. Chin, J. Fridlyand, J. Yeh, F. Baehner et al., A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes, Cancer Cell, vol.10, issue.6, pp.515-527, 2006.
DOI : 10.1016/j.ccr.2006.10.008

J. Sikora, G. Dworacki, and J. Zeromski, Expression of Fas and Fas Ligand and Apoptosis in Tumor-Associated Lymphocytes and in Tumor Cells from Malignant Pleural Effusions, Natural Immunity, vol.16, issue.5-6, pp.244-255, 1998.
DOI : 10.1159/000069450

J. Muppidi, J. Tschopp, and R. Siegel, Life And Death Decisions, Immunity, vol.21, issue.4, pp.461-465, 2004.
DOI : 10.1016/j.immuni.2004.10.001

J. Song, M. Tse, A. Bellail, S. Phuphanich, F. Khuri et al., Lipid Rafts and Nonrafts Mediate Tumor Necrosis Factor Related Apoptosis-Inducing Ligand Induced Apoptotic and Nonapoptotic Signals in Non Small Cell Lung Carcinoma Cells, Cancer Research, vol.67, issue.14, pp.6946-6956, 2007.
DOI : 10.1158/0008-5472.CAN-06-3896

H. Grassmé, A. Cremesti, R. Kolesnick, and E. Gulbins, Ceramide-mediated clustering is required for CD95-DISC formation, Oncogene, vol.22, issue.35, 2003.
DOI : 10.1038/sj.onc.1206540

M. Dimanche-boitrel, O. Meurette, A. Rebillard, and S. Lacour, Role of early plasma membrane events in chemotherapy-induced, Cell death Drug Resist Updat, vol.8, 2005.

S. Martin, D. Phillips, K. Szekely-szucs, L. Elghazi, F. Desmots et al., Cyclooxygenase-2 Inhibition Sensitizes Human Colon Carcinoma Cells to TRAIL-Induced Apoptosis through Clustering of DR5 and Concentrating Death-Inducing Signaling Complex Components into Ceramide-Enriched Caveolae, Cancer Research, vol.65, issue.24, pp.11447-11458, 2005.
DOI : 10.1158/0008-5472.CAN-05-1494

M. Moulin, S. Carpentier, T. Levade, and A. Arrigo, Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis, Apoptosis, vol.3, issue.9, pp.1703-1720, 2007.
DOI : 10.1007/s10495-007-0096-2

URL : https://hal.archives-ouvertes.fr/hal-00179322

R. Johnstone, A. Frew, and M. Smyth, The TRAIL apoptotic pathway in cancer onset, progression and therapy, Nature Reviews Cancer, vol.3, issue.10, pp.782-798, 2008.
DOI : 10.1038/sj.leu.2403491

W. Hallett, E. Ames, M. Motarjemi, I. Barao, A. Shanker et al., Sensitization of Tumor Cells to NK Cell-Mediated Killing by Proteasome Inhibition, The Journal of Immunology, vol.180, issue.1, pp.163-170, 2008.
DOI : 10.4049/jimmunol.180.1.163