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Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit.

Abstract : AMP-activated protein kinase (AMPK) plays a pivotal role in regulating cellular energy metabolism. We previously showed that AMPKalpha1-/- mice develop moderate anemia associated with splenomegaly and high reticulocytosis. Here, we report that splenectomy of AMPKalpha1-/- mice worsened anemia supporting evidence that AMPKalpha1-/- mice developed a compensatory response through extramedullary erythropoiesis in the spleen. Transplantation of bone marrow from AMPKalpha1-/- mice into wild-type recipients recapitulated the hematologic phenotype. Further, AMPKalpha1-/- red blood cells (RBC) showed less deformability in response to shear stress limiting their membrane flexibility. Thus, our results highlight the crucial role of AMPK to preserve RBC integrity.
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https://www.hal.inserm.fr/inserm-00514852
Contributor : Benoit Viollet <>
Submitted on : Friday, September 3, 2010 - 2:14:48 PM
Last modification on : Thursday, June 4, 2020 - 10:24:03 AM
Long-term archiving on: : Saturday, December 4, 2010 - 2:50:03 AM

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Marc Foretz, Soizic Guihard, Jocelyne Leclerc, Véronique Fauveau, Jean-Pierre Couty, et al.. Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit.. FEBS Letters, Wiley, 2010, 584 (16), pp.3667-71. ⟨10.1016/j.febslet.2010.07.041⟩. ⟨inserm-00514852⟩

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