Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit. - Archive ouverte HAL Access content directly
Journal Articles FEBS Letters Year : 2010

Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit.

(1) , (1) , (1) , (1) , (1) , (2) , (1) , (1) , (1) , (1)
1
2
Marc Foretz
Soizic Guihard
  • Function : Author
Jocelyne Leclerc
  • Function : Author
Murielle Gaudry
  • Function : Author
Sophie Vaulont
  • Function : Author
Benoit Viollet
Connectez-vous pour contacter l'auteur

Abstract

AMP-activated protein kinase (AMPK) plays a pivotal role in regulating cellular energy metabolism. We previously showed that AMPKalpha1-/- mice develop moderate anemia associated with splenomegaly and high reticulocytosis. Here, we report that splenectomy of AMPKalpha1-/- mice worsened anemia supporting evidence that AMPKalpha1-/- mice developed a compensatory response through extramedullary erythropoiesis in the spleen. Transplantation of bone marrow from AMPKalpha1-/- mice into wild-type recipients recapitulated the hematologic phenotype. Further, AMPKalpha1-/- red blood cells (RBC) showed less deformability in response to shear stress limiting their membrane flexibility. Thus, our results highlight the crucial role of AMPK to preserve RBC integrity.
Fichier principal
Vignette du fichier
ms_RBC_alpha1_FEBSLett_HAL.pdf (978.72 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00514852 , version 1 (03-09-2010)

Identifiers

Cite

Marc Foretz, Soizic Guihard, Jocelyne Leclerc, Véronique Fauveau, Jean-Pierre Couty, et al.. Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit.. FEBS Letters, 2010, 584 (16), pp.3667-71. ⟨10.1016/j.febslet.2010.07.041⟩. ⟨inserm-00514852⟩
191 View
408 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More