Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles FEBS Letters Year : 2010

Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit.

Marc Foretz
Soizic Guihard
  • Function : Author
Jocelyne Leclerc
  • Function : Author
Murielle Gaudry
  • Function : Author
Sophie Vaulont
  • Function : Author
Benoit Viollet
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Abstract

AMP-activated protein kinase (AMPK) plays a pivotal role in regulating cellular energy metabolism. We previously showed that AMPKalpha1-/- mice develop moderate anemia associated with splenomegaly and high reticulocytosis. Here, we report that splenectomy of AMPKalpha1-/- mice worsened anemia supporting evidence that AMPKalpha1-/- mice developed a compensatory response through extramedullary erythropoiesis in the spleen. Transplantation of bone marrow from AMPKalpha1-/- mice into wild-type recipients recapitulated the hematologic phenotype. Further, AMPKalpha1-/- red blood cells (RBC) showed less deformability in response to shear stress limiting their membrane flexibility. Thus, our results highlight the crucial role of AMPK to preserve RBC integrity.
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Dates and versions

inserm-00514852 , version 1 (03-09-2010)

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Marc Foretz, Soizic Guihard, Jocelyne Leclerc, Véronique Fauveau, Jean-Pierre Couty, et al.. Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit.. FEBS Letters, 2010, 584 (16), pp.3667-71. ⟨10.1016/j.febslet.2010.07.041⟩. ⟨inserm-00514852⟩
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