Skip to Main content Skip to Navigation
Journal articles

Increased phosphorylation of vimentin in noninfiltrative meningiomas.

Abstract : BACKGROUND: Tissue invasion or tissue infiltration are clinical behaviors of a poor-prognosis subset of meningiomas. We carried out proteomic analyses of tissue extracts to discover new markers to accurately distinguish between infiltrative and noninfiltrative meningiomas. METHODOLOGY/PRINCIPAL FINDINGS: Protein lysates of 64 different tissue samples (including two brain-invasive and 32 infiltrative tumors) were submitted to SELDI-TOF mass spectrometric analysis. Mass profiles were used to build up both unsupervised and supervised hierarchical clustering. One marker was found at high levels in noninvasive and noninfiltrative tumors and appeared to be a discriminative marker for clustering infiltrative and/or invasive meningiomas versus noninvasive meningiomas in two distinct subsets. Sensitivity and specificity were 86.7% and 100%, respectively. This marker was purified and identified as a multiphosphorylated form of vimentin, a cytoskeletal protein expressed in meningiomas. CONCLUSIONS/SIGNIFICANCE: Specific forms of vimentin can be surrogate molecular indicators of the invasive/infiltrative phenotype in tumors.
Complete list of metadatas

Cited literature [41 references]  Display  Hide  Download
Contributor : Jean-Paul Issartel <>
Submitted on : Wednesday, September 1, 2010 - 3:30:35 PM
Last modification on : Friday, November 6, 2020 - 4:03:16 AM
Long-term archiving on: : Thursday, December 2, 2010 - 2:47:11 AM


Publisher files allowed on an open archive



CEA | U836 | UGA


Ali Bouamrani, Claire Ramus, Emmanuel Gay, Laurent Pelletier, Myriam Cubizolles, et al.. Increased phosphorylation of vimentin in noninfiltrative meningiomas.. PLoS ONE, Public Library of Science, 2010, 5 (2), pp.e9238. ⟨10.1371/journal.pone.0009238⟩. ⟨inserm-00514192⟩



Record views


Files downloads