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P. J. Newman, M. C. Berndt, J. Gorski, G. C. White, S. Lyman et al., PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily, Science, vol.247, issue.4947, pp.1219-1222, 1990.
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I. N. Bird, J. H. Spragg, A. Ager, and N. Matthews, Studies of lymphocyte transendothelial migration: analysis of migrated cell phenotypes with regard to CD31 (PECAM-1), CD45RA and CD45RO, Immunology, vol.80, pp.553-560, 1993.

Y. Tada, S. Koarada, F. Morito, O. Ushiyama, Y. Haruta et al., Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1, Arthritis & Rheumatism, vol.40, issue.11, pp.3280-3290, 2003.
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D. K. Newton-nash and P. J. Newman, A new role for platelet-endothelial cell adhesion molecule-1 (CD31): inhibition of TCR-mediated signal transduction, J Immunol, vol.163, pp.682-688, 1999.

D. Graesser, A. Solowiej, M. Bruckner, E. Osterweil, A. Juedes et al., Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1???deficient mice, Journal of Clinical Investigation, vol.109, issue.3, pp.383-392, 2002.
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M. X. Wong, J. D. Hayball, P. M. Hogarth, and D. E. Jackson, The Inhibitory Co-Receptor, PECAM-1 Provides a Protective Effect in Suppression of Collagen-Induced Arthritis, Journal of Clinical Immunology, vol.48, issue.11, pp.19-28, 2005.
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D. K. Molthen and . Newman, Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient mice, Arterioscler Thromb Vasc Biol, vol.28, pp.1996-2002, 2008.

H. Stockinger, W. Schreiber, O. Majdic, W. Holter, D. Maurer et al., Phenotype of human T cells expressing CD31, a molecule of the immunoglobulin supergene family, Immunology, vol.75, pp.53-58, 1992.

A. Thiel, J. Schmitz, S. Miltenyi, and A. Radbruch, CD45RA-expressing memory/effector Th cells committed to production of interferon-?? lack expression of CD31, Immunology Letters, vol.57, issue.1-3, pp.189-192, 1997.
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C. E. Demeure, D. G. Byun, L. P. Yang, N. Vezzio, and G. Delespesse, CD31 (PECAM-1) is a differentiation antigen lost during human CD4 T-cell maturation into Th1 or Th2 effector cells, Immunology, vol.88, issue.1, pp.110-115, 1996.
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S. Kohler and A. Thiel, Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets, Blood, vol.113, issue.4, pp.769-774, 2009.
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M. Albelda and P. J. Newman, Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form, J Biol Chem, vol.269, pp.17183-17191, 1994.

J. L. Zehnder, K. Hirai, M. Shatsky, J. L. Mcgregor, L. J. Levitt et al., The cell adhesion molecule CD31 is phosphorylated after cell activation. Down-regulation of CD31 in activated T lymphocytes, J Biol Chem, vol.267, pp.5243-5249, 1992.

N. Ilan, A. Mohsenin, L. Cheung, and J. A. Madri, PECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics, The FASEB Journal, vol.15, issue.2, pp.362-372, 2001.
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P. L. Yun, A. A. Decarlo, C. C. Chapple, and N. Hunter, Functional Implication of the Hydrolysis of Platelet Endothelial Cell Adhesion Molecule 1 (CD31) by Gingipains of Porphyromonas gingivalis for the Pathology of Periodontal Disease, Infection and Immunity, vol.73, issue.3, pp.1386-1398, 2005.
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E. W. Dempsey and . Raines, Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17), J Biol Chem, vol.278, pp.37459-37464, 2003.

M. P. Mendez, S. B. Morris, S. Wilcoxen, E. Greeson, B. Moore et al., Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury, AJP: Lung Cellular and Molecular Physiology, vol.290, issue.5, pp.962-970, 2006.
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E. A. Eugenin, R. Gamss, C. Buckner, D. Buono, R. S. Klein et al., Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS, Journal of Leukocyte Biology, vol.79, issue.3, pp.444-452, 2006.
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J. Fawcett, C. Buckley, C. L. Holness, I. N. Bird, J. H. Spragg et al., Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts, The Journal of Cell Biology, vol.128, issue.6, pp.1229-1241, 1995.
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H. C. Yan, J. M. Pilewski, Q. Zhang, H. M. Delisser, L. Romer et al., Localization of Multiple Functional Domains on Human PECAM-1 (CD31) by Monoclonal Antibody Epitope Mapping, Cell Adhesion and Communication, vol.267, issue.1, pp.45-66, 1995.
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M. Gaston, A. Lemitre, A. Nicoletti, and . Lafont, Reduced immunoregulatory CD31+ T cells in the blood of atherosclerotic mice with plaque thrombosis, Arterioscler Thromb Vasc Biol, vol.25, pp.1659-1664, 2005.

J. L. Zehnder, M. Shatsky, L. L. Leung, E. C. Butcher, J. L. Mcgregor et al., Involvement of CD31 in lymphocyte-mediated immune responses: importance of the membrane-proximal immunoglobulin domain and identification of an inhibiting CD31 peptide, Blood, vol.85, pp.1282-1288, 1995.

G. Caligiuri, P. Rossignol, P. Julia, E. Groyer, D. Mouradian et al., Reduced Immunoregulatory CD31+ T Cells in Patients With Atherosclerotic Abdominal Aortic Aneurysm, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.26, issue.3, pp.618-623, 2006.
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Y. Chen, P. G. Schlegel, N. Tran, D. Thompson, J. L. Zehnder et al., Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease, Blood, vol.89, pp.1452-1459, 1997.

W. A. Muller, M. E. Berman, P. J. Newman, H. M. Delisser, and S. M. Albelda, A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31), Journal of Experimental Medicine, vol.175, issue.5, pp.1401-1404, 1992.
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E. F. Vernon-wilson, F. Aurade, and S. B. Brown, CD31 promotes ??1 integrin-dependent engulfment of apoptotic Jurkat T lymphocytes opsonized for phagocytosis by fibronectin, Journal of Leukocyte Biology, vol.79, issue.6, pp.1260-1267, 2006.
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C. W. Wong, G. Wiedle, C. Ballestrem, B. Wehrle-haller, S. Etteldorf et al., PECAM-1/CD31 Trans-homophilic Binding at the Intercellular Junctions Is Independent of Its Cytoplasmic Domain; Evidence for Heterophilic Interaction with Integrin alpha vbeta 3 in Cis, Molecular Biology of the Cell, vol.11, issue.9, pp.3109-3121, 2000.
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P. J. Choi, K. T. Newman, T. Preissner, S. Chavakis, and . Santoso, The neutrophilspecific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31), J Biol Chem, vol.282, pp.23603-23612, 2007.

J. P. Newton, C. D. Buckley, E. Y. Jones, and D. L. Simmons, Residues on Both Faces of the First Immunoglobulin Fold Contribute to Homophilic Binding Sites of PECAM-1/CD31, Journal of Biological Chemistry, vol.272, issue.33, pp.20555-20563, 1997.
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J. P. Couty, C. Rampon, M. Leveque, M. P. Laran-chich, S. Bourdoulous et al., PECAM-1 engagement counteracts ICAM-1- induced signaling in brain vascular endothelial cells Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology, J Neurochem Arterioscler Thromb Vasc Biol, vol.103, issue.23, pp.793-801953, 2003.

A. Khare, S. Shetty, K. Ghosh, D. Mohanty, and S. Chatterjee, Evaluation of markers of endothelial damage in cases of young myocardial infarction, Atherosclerosis, vol.180, issue.2, pp.375-380, 2005.
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H. Wei, L. Fang, S. H. Chowdhury, N. Gong, Z. Xiong et al., Platelet-endothelial cell adhesion molecule-1 gene polymorphism and its soluble level are associated with severe coronary artery stenosis in Chinese Singaporean, Clinical Biochemistry, vol.37, issue.12, pp.1091-1097, 2004.
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B. Kuenz, A. Lutterotti, M. Khalil, R. Ehling, C. Gneiss et al., Plasma levels of soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin are associated with relapsing-remitting disease course of multiple sclerosis, Journal of Neuroimmunology, vol.167, issue.1-2, pp.143-1491623, 2005.
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R. Goel, B. Boylan, L. Gruman, P. J. Newman, P. E. North et al., The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis, AJP: Gastrointestinal and Liver Physiology, vol.293, issue.6, pp.1205-1214, 2007.
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E. Groyer, A. Nicoletti, H. Ait-oufella, J. Khallou-laschet, A. Varthaman et al., Atheroprotective Effect of CD31 Receptor Globulin Through Enrichment of Circulating Regulatory T-Cells, Journal of the American College of Cardiology, vol.50, issue.4, pp.344-350, 2007.
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