Skip to Main content Skip to Navigation
Journal articles

Post-transcriptional controls - adding a new layer of regulation to clock gene expression.

Abstract : Living organisms undergo biochemical, physiological and behavioral cycles with periods ranging from seconds to years. Cycles with intermediate periods are governed by endogenous clocks that depend on oscillating gene expression. Here we illustrate the modalities and specific functions of post-transcriptional control of gene expression (exerted on pre-mRNAs and mRNAs) in biological clocks through two examples: the circadian clock and the vertebrate somite segmentation clock, an embryonic clock with a period far below a day. We conclude that both constitutive and cyclic post-transcriptional controls underpin clock function.
Document type :
Journal articles
Complete list of metadatas

Cited literature [72 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00511205
Contributor : Hervé de Villemeur <>
Submitted on : Tuesday, August 24, 2010 - 10:20:44 AM
Last modification on : Wednesday, May 16, 2018 - 11:22:33 AM
Long-term archiving on: : Thursday, November 25, 2010 - 2:35:06 AM

File

Cibois_TCB_HAL.pdf
Files produced by the author(s)

Identifiers

Citation

Marie Cibois, Carole Gautier-Courteille, Vincent Legagneux, Luc Paillard. Post-transcriptional controls - adding a new layer of regulation to clock gene expression.. Trends in Cell Biology, Elsevier, 2010, 20 (9), pp.533-41. ⟨10.1016/j.tcb.2010.06.004⟩. ⟨inserm-00511205⟩

Share

Metrics

Record views

371

Files downloads

594